外周血嗜酸性粒细胞水平对AECOPD患者预后的评估价值  

Value of eosinophil as a serum marker to assess the prognosis of AECOPD

作　　者：张莹莹[1,2] 李娜苗 范亚莉 董娅 赵钰玲[1,2] 李东繁 李建英[1] Zhang Yingying;Li Namiao;Fan Yali(Xi’an Central Hospital of Xi’an Jiaotong University,Xi’an 710003)

机构地区：[1]西安交通大学附属西安市中心医院,西安710003 [2]延安大学医学院,延安716000

出　　处：《陕西医学杂志》2018年第5期561-563,共3页Shaanxi Medical Journal

基　　金：陕西省中医药管理局面上项目(JCMS062);西安市科技攻关项目[SF-1509(1)]

摘　　要：目的:探讨外周血嗜酸性粒细胞水平在慢性阻塞性肺疾病急性加重期(AECOPD)患者预后中的评估价值。方法:慢性阻塞性肺疾病急性加重期的患者共68例,收集患者的基本信息、入院24h内的血常规、Hs-CRP、血气分析、住院天数、费用、1年内再入院情况及生存情况等资料,根据嗜酸性粒细胞百分比(EOS%)将患者分为EOS%>2%(嗜酸性粒细胞组,组1)及EOS%≤2%(非嗜酸性粒细胞组,组2)。结果:两组患者年龄、性别、吸烟史、合并症比较差异无统计学意义(P>0.05);嗜酸性粒细胞组患者中性粒细胞水平为(4.42±1.88)×10~9/L,低于非嗜酸性粒细胞组(5.69±2.56)×10~9/L,两组比较有统计学差异(P<0.05);嗜酸性粒细胞组患者外周血Hs-CRP水平为(8.89±1.67)mg/L,明显低于非嗜酸性粒细胞组(13.44±2.40)mg/L,两组比较有统计学差异(P<0.05);嗜酸性粒细胞组患者住院天数(7.44±1.93)d,非嗜酸性粒细胞组住院天数(8.82±1.70)d,两组比较有统计学差异(P<0.05);嗜酸性粒细胞组1年内再入院率5.9%,非嗜酸性粒细胞组1年内再入院率26.5%,两组比较有统计学差异(P<0.05);嗜酸性粒细胞1年内病死2例,非嗜酸性粒细胞1年病死9例,两组比较有统计学差异(P<0.05)。结论:嗜酸性粒细胞组的慢性阻塞性肺疾病急性加重期患者Hs-CRP水平较低,住院天数较短、再住院率及病死率均较低,提示外周血嗜酸性粒细胞水平可作为判断其预后的一项生物学指标。objective:To discuss the value of eosinophil as a serum marker to assess the prognosis of AECOPD.Methods:A retrospective observational cohort study was carried out in our department about the AECOPD patients from January 2015 to June 2016.The related information was registered its forblood routine,blood gas,Hs-CRP,duration of hospital stay,cost,re-hospital rate and survival situation.They were divided into two groups according to peripheral blood eosinophil level:the group 1 with eosinophil percentage>2%and the group 2 with non-eosinophil percentage≤2%.Results:There was no statistically significant difference in age,sex,smoking history,complications between two groups of patients,compared with the group 2,Hs-CRP and neutrophils level decreased obviously(P<0.05),and the length of the hospital stay of patients in group 2 was significant longer than that of the patients in group 1(P<0.05),the re-hospital rate and survival situation in group 1 was lower than group 2(P<0.05).Conclusion:AECOPD patients with a high level of peripheral blood eosinophil have lower Hs-CRP,neutrophils level,shorter hospital stay,low ospitalization rate and mortality,which suggests that the peripheral blood eosinophil levels can be used as an important biological indicator for evaluating the disease prognosis of AECOPD.

关 键 词：肺疾病 慢性阻塞性 预后 嗜酸性粒细胞 

分 类 号：R562.21[医药卫生—呼吸系统]