血浆t-PA、PAI-1、D-D和vWF:Ag水平检测在下肢关节置换术后并发下肢深静脉血栓形成中的价值研究  

The application value of plasma t-PA,PAI-1,D-D and vWF:Ag levels after replacement operation of lower limb joints with deep vein thrombus form

作　　者：程永红[1] 张熊 李毅[3] Cheng Yonghong;Zhang Xiong;Li Yi(Department of Laboratory,The Central Hospital of Shangluo City,Shangluo 726000)

机构地区：[1]陕西省商洛市中心医院检验科,商洛726000 [2]陕西省咸阳市第一人民医院检验科,咸阳712000 [3]西安交通大学附属红会医院足踝外科,西安710054

出　　处：《陕西医学杂志》2018年第5期665-667,共3页Shaanxi Medical Journal

基　　金：陕西省科学技术研究发展计划项目(2016SF-333)

摘　　要：目的:探讨血浆组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活抑制物-1(PAI-1)、D-二聚体(D-D)和血管性血友病因子抗原(vWF:Ag)水平检测在下肢关节置换术后并发下肢深静脉血栓形成中的应用价值。方法:收集行下肢关节置换术治疗的90例患者的血清及临床资料,依据是否发生下肢深静脉血栓形成(DVT)及是否出现临床症状分为DVT组、有症状组和无DVT组,其中DVT组42例,无DVT组48例、有症状组18例。采用全自动血凝仪检测血浆t-PA、PAI-1、D-D和vWF:Ag水平。比较分析以上指标的变化与DVT的关系。结果:与无DVT组比较,DVT组和有症状组血浆t-PA水平显著降低,PAI-1、vWF:Ag和D-D水平显著增高,差异有统计学意义(P<0.01);与DVT组比较,有症状组血浆t-PA水平显著降低(P<0.01),PAI-1、D-D和vWF:Ag水平显著增高,差异有统计学意义(P<0.01)。DVT组和有症状组的t-PA、PAI-1和vWF:Ag水平与D-D水平具有显著相关性(P<0.01)。结论:检测血浆t-PA、PAI-1、D-D和vWF:Ag水平可预测下肢关节置换术后DVT的发生,估计病情的发展状况。Objective:To investigate the application value of plasma t-PA,PAI-1,D-D and vWF:Ag levels after replacement operation of lower limb joints with deep vein thrombus form.Methods:The serum and clinical datas of 90 patients were collected,devided into DVT groups(42cases),non-DVT group(48 cases)and symptomatic group(18 cases)on the basis whether happened DVT or emerged symptoms.The levels of plasma t-PA,PAI-1,D-D and vWF:Ag were detected by automatic blood coagulation instrument in comparative analysis of the changes on plasma t-PA,PAI-1,D-D and VWF:Ag levels in the relations with DVT.Results:Compared with plasma t-PA,PAI-1,D-D and vWF:Ag levels in the non-DVT group,t-PA levels in the DVT groups and symptomatic group significantly lowered,and PAI-1,vWF:Ag and D-D levels significantly rose,the difference had statistical significance(P<0.01);Compared with those in the DVT group,t-PA levels in the symptomatic group significantly lowered,and PAI-1,vWF:Ag and D-D levels significantly rose,the difference had statistical significance(P<0.01);The plasma t-PA and PAI 1 and vWF:Ag levels in the DVT groups and symptomatic group had a significant correlation with D-D levels(P<0.01).Conclusion:Detection of t-PA,PAI-1,D-D and vWF:Ag levels can predict in happaning DVT in after replacement operation of lower limb joints,and estimate the development of the disease condition.

关 键 词：关节成形术 置换 静脉血栓形成 纤溶酶原激活剂 纤溶酶原激活物抑制物1 嘧啶二聚体 @血管性血友病因子抗原 

分 类 号：R658.3[医药卫生—外科学]