核苷类抗疱疹病毒药物的研究进展  

Research progress on nucleoside drugs against herpes virus

作　　者：吉宁[1] 赵行 曾昕[1] 陈谦明[1] Ji Ning;Zhao Hang;Zeng Xin;Chen Qianming(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院,成都610041

出　　处：《国际口腔医学杂志》2018年第3期351-357,共7页International Journal of Stomatology

基　　金：国家自然科学基金(81621062;81500860)~~

摘　　要：疱疹病毒可引起多种疾病,如角膜炎、唇疱疹、带状疱疹、生殖器疱疹、脑炎等,目前临床上用于治疗疱疹性疾病的药物主要是以阿昔洛韦为代表的核苷类药物,本文对已上市及正在研究中的核苷类抗疱疹药物及其作用机制作简要介绍。Herpes virus can cause many diseases,such as keratitis,cold sores,herpes zoster,genital herpes,and encephalitis,etc.Aciclovir and related nucleoside analogues are gold standard molecules for treatment of herpetic diseases in clinical over the past decades.Here,the recent progress of anti-herpes virus nucleoside agents are summarized in this review,including structure characteristic,antiviral mechanism and clinical application.

关 键 词：疱疹病毒 核苷类药物 作用机制 

分 类 号：R97[医药卫生—药品]