中脑导水管周围灰质调控恐惧反应的研究进展  

Research Progress on the Regulating Effect of Periaqueductal Gray in Fear Response

作　　者：张浩 谭洁[1] ZHANG Hao;TAN Jie(Department of Pathology and Pathophysiology,Guilin Medical University,GuangxiGuilin 541004,China)

机构地区：[1]广西壮族自治区桂林医学院病理学与病理生理学教研室,广西桂林541004

出　　处：《临床医药文献电子杂志》2018年第7期183-185,187,共4页Electronic Journal of Clinical Medical Literature

基　　金：国家自然科学基金(31360244)

摘　　要：中脑导水管周围灰质(PAG)作为调控恐惧反应(Fear Response)的重要脑区,起到联系恐惧反应神经环路内上游杏仁核和下游脊髓背侧后脚的"中继站"作用。研究PAG在恐惧反应中的作用对于深入了解恐惧反应的生理机制和神经环路有着重要的意义。本文从PAG的不同解剖分区在先天性恐惧和条件性恐惧中的作用、PAG内不同类型的神经元对恐惧反应的调控、以及参与调控恐惧反应的神经环路三个方面总结了最新的研究进展,并对这一领域的发展方向进行了展望。The periaqueductal gray(PAG)is one of the most significant brain nuclei in fear response regulation.PAG transmits the information from amygdala to spinal/trigeminal dorsal horn.To study the functional role of PAG in fear response will give us further insight of the mechanism about formation and consolidation of fear response.We summarize the recent research progress on PAG in the following three aspects:the function of morphological subdivisions of PAG in innate and learned fear,different roles of neuronal subtypes in regulating fear response,and neural circuits involved in fear response.Finally,a new direction for studying fear response mechanism is provided.

关 键 词：中脑导水管周围灰质 恐惧反应 神经环路 

分 类 号：R4[医药卫生—临床医学]