曲美他嗪对急性ST段抬高型心肌梗死患者缺血/再灌注诱导心肌细胞凋亡的影响  

Effect of trimetazidine on myocardial apoptosis induced by ischemia/reperfusion in patients with acute ST segment elevation myocardial infarction

作　　者：唐泉[1] 银剑斌[1] 吴刚[1] 蒋洪昆[1] TANG Quan;YIN Jian-bin;WU Gang;JIANG Hong-kun(Liuzhou People's Hospital,Guangxi Liuzhou 545006,China)

机构地区：[1]柳州市人民医院,广西柳州545006

出　　处：《临床医药文献电子杂志》2018年第16期9-10,共2页Electronic Journal of Clinical Medical Literature

基　　金：广西壮族自治区卫生厅自筹经费科研课题(编号:Z2011289)

摘　　要：目的探讨曲美他嗪对急性ST段抬高型心肌梗死患者缺血/再灌注(I/R)诱导的心肌细胞凋亡的影响。方法选取2012年2月~2014年6月69例在我院接受直接经皮冠状动脉介入治疗(PCI)的急性ST段抬高型心肌梗死(STEMI)患者,随机分为观察组(34例)和对照组(35例)。两组患者均接受冠心病常规治疗,观察组加用曲美他嗪治疗。对两组患者血清细胞色素C和左室射血分数(LVEF)进行比较。结果观察组术后24小时和48小时血清细胞色素C水平均低于对照组,术后1个月观察组LVEF高于对照组,差异有统计学意义(P<0.05)。结论曲美他嗪可以减少STEMI患者I/R诱导的心肌细胞凋亡,利于心功能恢复。Objective To investigate the effects of trimetazidine on ischemia/reperfusion-induced cardiomyocytes apoptosis in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Sixty-nine patients with STEMI who underwent primary percutaneous coronary intervention(PCI)in our hospital were randomly divided into observation group(n=34)and control group(n=35)from February 2012 to June 2014.Both groups were treated with conventional treatment of coronary heart disease,and the observation group was additionally treated with trimetazidine.The serum cytochrome c and left ventricular ejection fraction(LVEF)were compared in two groups.Results The serum level of cytochrome c in observation group was significant lower than those of the control group at 24 hours and 48 hours after PCI.The LVEF of observation group was significant higher than the control group(P<0.05)after 1 month.Conclusion Trimetazidine reduced ischemia/reperfusion-induced cardiomyocytes apoptosis in patients with STEMI and facilitated the recovery of cardiac function.

关 键 词：急性心肌梗死 缺血/再灌注损伤 细胞凋亡 细胞色素C 

分 类 号：R541.4[医药卫生—心血管疾病]