观察普通胰岛素与诺和锐治疗糖尿病酮症酸中毒的治疗效果  

To observe the therapeutic effect of normal insulin and naoxi in the treatment of diabetic ketoacidosis

作　　者：冯玉梅[1] 申志才[1] 李卉[1] FENG Yu-mei;SHEN Zhi-cai;LI Hui(Sichuan mianyang people's hospital,sichuan mianyang 621000,China)

机构地区：[1]四川省绵阳市人民医院,四川绵阳621000

出　　处：《临床医药文献电子杂志》2018年第18期5-8,共4页Electronic Journal of Clinical Medical Literature

摘　　要：目的观察普通胰岛素与诺和锐治疗糖尿病酮症酸中毒的治疗效果。方法选取我院2015年2月~2016年12月在本院接受观察普通胰岛素与诺和锐治疗糖尿病酮症酸中毒的治疗效果治疗的100例患者作为研究对象,并按随机数字表法将其平均分为观察组与对照组,各50例,观察组使用的治疗药物为诺和锐,对照组则是普通胰岛素。比较两组的总有效率、不良反应发生率、治疗情况、低血糖发生情况。结果观察组的总有效率为96.00%,其中显效42例、有效6例、无效2例,对照组的总有效率为82.00%,其中显效35例、有效6例、无效9例,经对比,对照组的总有效率低于观察组,差异有统计学意义(P<0.05);观察组的不良反应发生率为4.00%,其中瘙痒1例、发热0例、恶心1例,对照组的不良反应发生率为18.00%,其中瘙痒4例、发热2例、恶心3例,经对比,对照组的不良反应发生率高于观察组,差异有统计学意义(P<0.05);观察组尿酮转阴时间、尿酮体阴性后胰岛素用量以及纠正酸中毒时长均低于对照组,差异有统计学意义(P<0.05);对照组的夜间低血糖发生率为16.00%,中餐前低血糖发生率为18.00%,观察组的夜间低血糖发生率为2.00%,中餐前低血糖发生率为1.00%,经对比,对照组的夜间低血糖发生率、中餐前低血糖发生率均高于观察组,差异有统计学意义(P<0.05)。结论诺和锐治疗糖尿病酮症酸中毒具有极高的使用价值,其疗效理想,能显著改善患者的临床症状,降低低血糖发生率,安全指数高,此药值得在各大基层医院的临床治疗中大力推广。Objective To observe the therapeutic effect of normal insulin and Novolin on diabetic ketoacidosis.Methods A total of 100 patients who underwent treatment of diabetic ketoacidosis in our hospital from February 2015 to December 2016 were selected as the study subjects and treated with random number table The average was divided into the observation group and the control group,50 cases in each group.The observation group used Novolin as the therapeutic drug and the control group was normal insulin.The total effective rate,incidence of adverse reactions,treatment,hypoglycemia in both groups were compared.Results The total effective rate of the observation group was 96.00%,of which 42 cases were markedly effective,6 cases effective and 2 cases ineffective.The total effective rate of the control group was 82.00%,of which 35 cases were markedly effective,6 effective and 9 ineffective.The total effective rate of the control group was lower than that of the observation group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 4.00%,including 1 itching,0 fever,1 nausea and poor control The incidence of reaction was 18.00%,including 4 cases of pruritus,2 cases of fever and 3 cases of nausea.The incidence of adverse reactions in the control group was higher than that in the observation group(P<0.05)(P<0.05).The incidence of nocturnal hypoglycemia in control group was 16.00%,the incidence of hypoglycemia before meals was significantly lower than that in control group The incidence of hypoglycemia at night was 2.00%in the observation group and 1.00%in the pre-meal period.By contrast,the incidences of nocturnal hypoglycemia and pre-meal hypoglycemia in the control group were all higher than those in the observation group,Differences Statistically significant(P<0.05).Conclusions Nuo-Rui treatment of diabetic ketoacidosis has a very high value,the effect is ideal,can significantly improve the patient's clinical symptoms,reduce the incidence of hypoglycemia,high saf

关 键 词：胰岛素 诺和锐 糖尿病 酮症酸中毒 

分 类 号：R587.1[医药卫生—内分泌]