PEG功能化1,3-二唑盐的合成及在水相Heck反应中的研究  

Synthesis of PEG-functionalized azole salts and their applications in Heck reaction in water

作　　者：孙楠[1] 陈蒙 赵维 SUN Nan;CHEN Meng;ZHAO Wei(College of Chemical Engineer,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《浙江工业大学学报》2018年第3期255-261,共7页Journal of Zhejiang University of Technology

摘　　要：以商品化的聚乙二醇单甲醚为起始原料,通过三步反应制备了4种PEG功能化的1,3-二唑季铵盐(L1~L4),产物的收率都在90%以上.随后将上述4种产物作为水溶性卡宾前体分别和Na_2PdCl_4反应在线生成卡宾钯络合物并用于催化均相的水相Heck反应.优化实验结果表明:L1的催化性能最优,在纯水相中模型反应的TON值大于8 900.建立的催化体系对底物的适用性较好,可用于制备许多二苯乙烯类化合物,收率为51%~98%.该方法具有产物分离简便、收率高、催化剂用量少和环境友好等优点.Four PEG-functionalized azole salts(L1-L4)were designed and prepared from commercially available materials via a three-step sequence reaction.Their corresponding water soluble Pd-NHC catalysts,in-situ generated from the azole salts L1-L4 and Na 2PdCl 4 in water,showed impressive catalytic activity for aqueous Heck reaction.The experimental results showed that L1 exhibited better catalytic performance than their analogues L2-L4 and the catalyst TON was larger than 8 900 for model reaction.Under the optimal conditions,a wide range of substituted alkenes were achieved in good to excellent yields(51%-98%)from various aryl bromides and alkenes.It provided a green,facile and efficient method for the synthesis of stilbene compounds.

关 键 词：PEG功能化1 3-二唑盐 NA 2PdCl 4 HECK反应 水相均相催化 

分 类 号：O626.4[理学—有机化学]