microPET大鼠脑模板研究  

Research of microPET rat brain template

作　　者：沈小燕[1] 肖辉 乐孜纯[1] SHEN Xiaoyan;XIAO Hui;LE Zichun(College of Science,Zhejiang University of Technology,Hangzhou 310023,China)

机构地区：[1]浙江工业大学理学院,浙江杭州310023

出　　处：《浙江工业大学学报》2018年第3期332-336,共5页Journal of Zhejiang University of Technology

基　　金：浙江省自然科学基金资助项目(LQ14F050001)

摘　　要：小动物正电子发射断层扫描(PET,positron emission tomography)技术被广泛应用于各种神经科学的研究.为了便于进行不同个体或同一个体重复扫描数据的分析,通过对不同PET脑模板制作方法的比较,制作一个大鼠大脑的FDG-PET模板.实验中20只健康SD(Sprague dawley)大鼠大脑的PET扫描数据被纳入研究,分别建立了大鼠的MR-PET脑模板和synPET脑模板,同时比较了以这两种模板为标准进行配准时的配准精度.结果表明:使用MR-PET模板进行配准时的平均误差为1.818mm,误差范围为1.093~2.752mm;而使用synPET模板进行配准时的平均误差为2.009mm,误差范围在1.615~2.445mm.基于MR大鼠脑模板制作的MR-PET模板的配准误差要小于synPET模板.Small animal positron emission tomography(PET)technology is widely used in neuroscience studies.In order to facilitate the analysis between different subjects or between repeat scans of the same subject,FDG-PET template of rat brain was constructed using two methods.Twenty Sprague-Dawley rats were included for template construction.The MR-PET template and synPET template of rat brain were constructed respectively,and the accuracy of the two template registration were evaluated.The results showed that the average error when using MR-PET template for registration was 1.818 mm,and the error range was 1.093-2.752 mm,while the average error when using synPET template for registration was 2.009 mm,and the error range was 1.615 mm-2.445 mm.Therefore,FDG-PET rat brain template constructed based on MR rat brain template have high registration accuracy than the synPET template.

关 键 词：正电子发射断层扫描 PET模板 synPET脑模板 配准误差 

分 类 号：R814.42[医药卫生—影像医学与核医学] R741.02[医药卫生—放射医学]