慢性阻塞性肺疾病合并侵袭性肺曲霉病20例回顾性分析  

Chronic obstructive pulmonary disease complicated with invasive pulmonary aspergillosis were retrospectively analysis of 20 cases

作　　者：石宝玉 李勇[1] 徐晓[1] SHI Bao-yu;LI Yong;XU Xiao(Department of respiration of Suzhou Municipal Hospital,Jiangsu Suzhou 215000,China)

机构地区：[1]苏州市立医院本部呼吸科,江苏苏州215000

出　　处：《临床医药文献电子杂志》2017年第82期16046-16046,16053,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的分析慢性阻塞性肺疾病(COPD)合并侵袭性肺曲霉病(IPA)的危险因素,临床特点,诊断方法及治疗。方法回顾性分析我院收治的20例COPD合并IPA患者的临床资料、诊断、治疗及转归。结果 20例COPD合并肺曲霉病患者中18例有广谱抗生素使用史,14例有全身糖皮质激素应用史,存在喘息者16例,发热8例。20例患者均接受抗真菌治疗,13例治疗后症状好转出院,5例自行停药出院,机械通气8例,死亡2例,死亡原因均为多脏器功能衰竭。结论 COPD合并IPA患者应及时行IPA检查,早诊断早治疗。Objective Analysis of chronic obstructive pulmonary disease(COPD)complicated with invasive pulmonary aspergillosis(IPA)risk factors,clinical characteristics,diagnosis and treatment.Methods The clinical data,diagnosis,treatment and prognosis of 20 cases of COPD combined with IPA were analyzed retrospectively.Results 20 cases of COPD patients complicated with pulmonary aspergillosis in 18 cases with the history of use of broad-spectrum antibiotics,14 cases of systemic corticosteroid application history,16 cases had wheezing,8 cases of fever.The positive rate of GM in bronchoalveolar lavage fluid was 30%(6/20).All 20 patients were treated with antifungal therapy,13 cases were discharged after treatment,5 cases were discharged voluntarily,8 cases were mechanical ventilation,2 cases died,and the causes of death were multiple organ failure.Conclusion COPD patients with IPA should be examined by IPA in time,early diagnosis and early treatment.

关 键 词：慢性阻塞性肺疾病 肺曲霉病 快速诊断 

分 类 号：R563[医药卫生—呼吸系统]