不同剂量糖皮质激素治疗重症COPD急性加重期患者的疗效及安全性对比分析  

Comparative analysis of efficacy and safety of different doses of glucocorticoids in the treatment of severe acute exacerbation of COPD

作　　者：黄琴[1] 邹伦红 Huang Qin;Zou Lunhong(Department of respiratory medicine,Santai People's Hospital,Sichuan Mianyang 621100,China)

机构地区：[1]三台县人民医院呼吸内科,四川绵阳621100

出　　处：《临床医药文献电子杂志》2017年第73期14425-14426,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的探讨不同剂量糖皮质激素治疗重症慢性阻塞性肺疾病(CODP)急性加重期疗效、安全性。方法分别给予低剂量组和高剂量组的患者注射加基强的松龙40 mg/d80 mg/d静脉注射,疗程为五日。结果两组的总有效率和28 d后的病死率之间的比较,低剂量组不良反应的发生率,要低于高剂量组,差异有统计学意义(P<0.05)。结论对于慢性阻塞性肺疾病重症患者来说,应鼓励其使用低剂量的糖皮质激素策略进行试用,之后再根据病情选用最佳糖皮质激素剂量,并加以确定。Objective To investigate the efficacy and safety of different doses of glucocorticoids in the treatment of acute exacerbation pulmonary disease(CODP).Methods low dose group and high dose group were given intravenous methylprednisolone 40mg/d80mg/d strong base.Results the adverse reactions rate in the low dose group was lower group(P<0.05).A comparison between the total the fatality rate after 28d(P>0.05).Conclusion for patients with severe chronic obstructive pulmonary disease,corticosteroids should encourage the use of low doses of strategies for trial,then according to the condition of choosing the optimal dose of glucocorticoid,and confirmed.

关 键 词：糖皮质激素 慢性阻塞性肺疾病CODP 重症 不良反应 

分 类 号：R563.9[医药卫生—呼吸系统]