新诊断2型糖尿病患者早期胰岛素强化治疗后续治疗方案的临床分析  

Clinical analysis of the follow-up treatment of early insulin intensive therapy for newly diagnosed type 2 diabetes

作　　者：翟铁[1] 田雪品[1] 王晓军[1] 刘海英[1] 张艳秋 陶晶晶 ZHUO Tie;TIAN Xue-pin;WANG Xiao-jun;LIU Hai-ying;ZHANG Yan-qiu;TAO Jing-jing(Department of Endocrinology,Chengde Center Hospital,Hebei Chengde 067000,China)

机构地区：[1]承德市中心医院内分泌科,河北承德067000

出　　处：《临床医药文献电子杂志》2017年第104期20434-20435,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的分析新诊断2型糖尿病患者早期胰岛素强化治疗后续治疗方案的临床治疗效果。方法选取2014年1月~2016年12月我院收治的新诊断2型糖尿病患者120例作为研究对象,所有研究对象实施早期胰岛素强化治疗后续治疗方案,根据治疗方案的不同将120例患者分成3组,分别为基础胰岛素组、预混胰岛素组、磺脲类促胰岛素分泌剂组,各40例患者。3组结束后续治疗后均减少药物用量,给予生活干预指导,血糖控制不佳患者要口服二甲双胍治疗,经过1年随访,对比3组患者空腹血糖、空腹C肽等指标变化情况。结果随访治疗1年后,3组血糖控制效果均优于治疗前,空腹C肽等指标改善情况均优于治疗前,对比差异显著(P<0.05);磺脲类促胰岛素分泌组优于其它2组(P<0.05)。结论新诊断2型糖尿病患者实施磺脲类促胰岛素分泌治疗方案对血糖控制效果较好,对胰岛β细胞功能改善效果较为理想,值得推广应用。Objective To newly diagnose the effect of follow-up treatment of early intensive insulin therapy in type 2 diabetic patients.Methods 120 patients with newly diagnosed type 2 diabetes were enrolled in the followup treatment regimen of early intensive insulin therapy.They were basal insulin group,premixed insulin group and sulfonylurea insulin secretagogue group respectively.After one year of follow-up,fasting blood glucose and fasting C-peptide were compared among the three groups.Results After one year of follow-up,the blood sugar control effect of three groups were better than before treatment.The improvement of fasting C-peptide index was better than before treatment.The sulfonylurea insulin secretion group was superior to the other two groups(P<0.05).Conclusion The newly diagnosed type 2 diabetes mellitus patients with sulfonylurea-induced insulin secretion therapy is better for glycemic control.

关 键 词：新诊断 2型糖尿病 早期 胰岛素 强化治疗 后续治疗 

分 类 号：R587.1[医药卫生—内分泌]