心肾综合征发病机制和治疗的研究进展  

Progress on Pathogenesis and Treatment of Cardio-renal Syndrome

作　　者：刘茜[1] 周华[1] 瞿惠燕[1] 戎靖枫[1] 沙琬婧 王佩[1] 蔡婉[1] LIU Qian;ZHOU Hua;QU Hui-yan;RONG Jingfeng;SHA Wan-jing;WANG Pei;CAI Wan

机构地区：[1]上海中医药大学附属曙光医院心内科心血管研究所,上海市201203

出　　处：《实用心脑肺血管病杂志》2018年第2期1-5,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金面上项目(81373625);国家自然科学基金面上项目(81673753)

摘　　要：近10年来,心肾综合征(CRS)发病率逐年升高并逐渐引起人们密切关注。CRS的主要发病机制包括交感神经系统过度兴奋、肾素-血管紧张素-醛固酮系统(RAAS)过度激活、血流动力学障碍、炎性反应、氧化应激、贫血及分子信号通路异常等。CRS的主要治疗原则为改善心功能、肾功能及防治并发症,主要治疗方法包括药物治疗(正性肌力和血管活性药物、神经激素拮抗剂、利尿剂和重组人促红细胞生成素等)和超滤治疗。本文主要综述了CRS的发病机制及治疗方法,以期为临床有效诊治CRS提供参考。In the past 10 years,morbidity of cardio-renal syndrome(CRS)increased year by year and attracted more attentions.The pathogenesis of CRS mainly includes overexcitation of sympathetic nervous system and renin-angiotensinaldosterone system(RAAS),hemodynamic disturbance,inflammatory reaction,oxidative stress,anemia and molecular signaling pathway abnormity.The principal therapeutic principle of CRS mainly includes improving of cardiac function and renal function,preventing and treating complications,the main therapeutic methods includes drug therapy(including positive inotropic drugs,vasoactive drugs,neurohormonal antagonists,diuretic and recombinant human erythropoietin)and hemofiltration.This paper mainly reviewed the pathogenesis and treatment of CRS,to provide a reference for effective diagnosis and treatment of CRS.

关 键 词：心肾综合征 治疗 发病机制 综述 

分 类 号：R692.5[医药卫生—泌尿科学]