血清基质金属蛋白酶10水平与急性冠脉综合征的关系研究  

Relationship between Matrix Metalloproteinase-10 and Acute Coronary Syndrome

作　　者：李慧婷[1] 贺继忠 LI Hui-ting;HE Ji-zhong(Department of Cardiology,the People's Hospital of Yan'an,Yan'an 716000,China)

机构地区：[1]陕西省延安市人民医院心内科,716000

出　　处：《实用心脑肺血管病杂志》2018年第2期20-23,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨血清基质金属蛋白酶10(MMP-10)水平与急性冠脉综合征(ACS)的关系。方法选取2015年1月—2017年1月延安市人民医院心内科收治的ACS患者338例,根据疾病类型分为ST段抬高型心肌梗死(STEMI)组96例、非ST段抬高型心肌梗死(NSTEMI)组127例和不稳定型心绞痛(UAP)组115例;另选取同期于延安市人民医院体检健康者200例作为对照组。比较所有受试者一般资料、实验室检查指标、Gensini评分,血清MMP-10水平与ACS患者Gensini评分相关性分析采用Pearson相关性分析,绘制ROC曲线以评价血清MMP-10和心肌肌钙蛋白I(cTnI)水平对ACS的预测价值。结果 4组受试者性别、年龄、体质指数、吸烟史及血清三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);STEMI组、NSTEMI组、UAP组患者高血压病史、糖尿病病史、血脂异常发生率比较,差异无统计学意义(P>0.05);STEMI组、NSTEMI组患者血清cTnI水平高于对照组(P<0.05);STEMI组、NSTEMI组和UAP组患者血清超敏C反应蛋白(hs-CRP)、MMP-10水平高于对照组(P<0.05)。STEMI组患者Gensini评分高于UAP组(P<0.05)。Pearson相关性分析结果显示,血清MMP-10水平与ACS患者Gensini评分呈正相关(r=0.208,P<0.05)。绘制ROC曲线发现,血清MMP-10水平预测ACS的曲线下面积(AUC)为0.876[95%CI(0.847,0.904)],最佳截断值为5.99μg/L,灵敏度为0.728,特异度为0.910;血清cTnI水平预测ACS的AUC为0.930[95%CI(0.906,0.953)],最佳截断值为0.04μg/L,灵敏度为0.879,特异度为0.945。血清MMP-10水平预测ACS的AUC小于血清cTnI水平(P<0.05)。结论血清MMP-10水平与ACS的发生、发展有关,且其对ACS的发生有一定预测价值。Objective To investigate the relationship between serum matrix metalloproteinase-10(MMP-10)level and acute coronary syndrome(ACS).Methods From January 2015 to January 2017,a total of 338 patients with ACS were selected in the Department of Cardiology,the People's Hospital of Yan'an,and they were divided into STEMI group(with STEMI,n=96),NSTEMI group(with NSTEMI,n=127)and UAP group(with UAP,n=115)group according to the types of illness;meanwhile a total of 200 healthy people admitted to this hospital for physical examination were selected as control group.General information,laboratory examination results and Gensini score were compared in the four groups,Pearson correlation analysis was used to analyze the correlation between serum MMP-10 and Gensini score in patients with ACS,ROC curve was drawn to evaluate the predictive value of serum MMP-10 level and cTnI on ACS.Results No statistically significant differences of gender,age,BMI,smoking history,serum level of TG or LDL-C was found between the two groups(P>0.05),nor was medical history of hypertension or diabetes,or incidence of dyslipidemia was found in STEMI group,NSTEMI group and UAP group(P>0.05);serum cTnI in STEMI group and NSTEMI group was statistically significantly higher than that in control group,respectively(P<0.05);serum levels of hs-CRP and MMP-10 in STEMI group,NSTEMI group and UAP group were statistically significantly higher than those in control group(P<0.05).Gensini score in STEMI group was statistically significantly higher than that in UAP group(P<0.05).Pearson correlation analysis results showed that,serum MMP-10 was positively correlated with Gensini score in patients with ACS(r=0.208,P<0.05).ROC curve showed that,AUC of serum MMP-10 level in predicting ACS was 0.876〔95%CI(0.847,0.904)〕,the optimum truncation value was 5.99μg/L,the sensitivity was 0.728,the specificity was 0.910;AUC of serum cTnI level in predicting ACS was 0.930〔95%CI(0.906,0.953)〕,the optimum truncation value was 0.04μg/L,the sensitivity was 0.879,the specifi

关 键 词：急性冠脉综合征 基质金属蛋白酶10 预测 

分 类 号：R542.2[医药卫生—心血管疾病]