含服硝苯地平对基础状态桡动脉结构和功能的影响研究  

Impact of Sublingual Administration of Nifedipine on Basic Status Radial Artery Structure and Function

作　　者：甘泉[1] 刘德丰[1] 王庆胜[1] 刘丽[1] 毕希乐[1] GAN Quan;LIU De-feng;WANG Qing-sheng;LIU Li;BI Xi-le(The First Hospital of Qinhuangdao,Qinghuangdao 066000,China)

机构地区：[1]河北省秦皇岛市第一医院,066000

出　　处：《实用心脑肺血管病杂志》2018年第2期44-46,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：河北省医学科学研究重点课题计划项目(20170223)

摘　　要：目的探讨含服硝苯地平对基础状态桡动脉结构和功能的影响。方法选取2017年1—6月秦皇岛市第一医院诊断为冠心病或疑似冠心病需行冠状动脉造影或经皮冠状动脉介入治疗(PCI)患者60例,均于术前1 d含服硝苯地平,比较患者用药前及用药后5、15、30 min心率、平均动脉压、桡动脉直径、桡动脉收缩期峰值血流速度(SPV)、桡动脉阻力指数(RI)。结果患者用药前后心率和平均动脉压比较,差异无统计学意义(P>0.05)。用药后5、15 min桡动脉直径大于用药前,桡动脉SPV高于用药前(P<0.05);用药后5 min桡动脉RI低于用药前(P<0.05)。基础桡动脉直径≥2.73 mm患者34例,用药前后桡动脉直径比较,差异无统计学意义(P>0.05)。基础桡动脉直径<2.73 mm患者26例,用药后5 min、15 min桡动脉直径大于用药前(P<0.05)。用药后无一例患者发生诱发性心绞痛、头痛及心悸症状。结论含服硝苯地平对心率和平均动脉压无明显影响,但可影响基础状态桡动脉直径及血流动力学,且安全性较高。Objective To investigate the impact of sublingual administration of nifedipine on basic status radial artery structure and function.Methods A total of 60 patients with coronary heart disease or suspected as coronary heart disease undergoing coronary angiography or PCI were selected in the First Hospital of Qinhuangdao from January to June 2017,and all of them received sublingual administration of nifedipine 1 day before coronary angiography or PCI.Heart rate,MAP,diameter,systolic peak blood flow velocity(SPV)and resistance index(RI)of radial artery before sublingual administration,5,15 and 30 minutes after sublingual administration were compared.Results After sublingual administration,heart rate or MAP was not statistically significantly different compared with that before sublingual administration,respectively(P>0.05).After 5 and 15 minutes of sublingual administration,radial artery diameter was statistically significantly larger than that before sublingual administration,respectively,meanwhile SPV of radial artery was statistically significantly higher than that before sublingual administration,respectively(P<0.05);after 5 minutes of sublingual administration,RI of radial artery was statistically significantly lower than that before sublingual administration(P<0.05).In the 34 cases with basic radial artery diameter equal or over 2.73 mm,radial artery diameter after sublingual administration was not statistically significantly different compared with that before sublingual administration(P>0.05);in the 26 cases with basic radial artery diameter less than 2.73 mm,radial artery diameter 5 and 15 minutes after sublingual administration was statistically significantly larger than that before sublingual administration,respectively(P<0.05).No one occurred induced angina pectoris,headache or palpitation after sublingual administration.Conclusion Sublingual administration of nifedipine has no obvious impact on heart rate or MAP,but may affect the basic status radial artery diameter and haemodynamics,with relatively high

关 键 词：硝苯地平 桡动脉 结构 功能 

分 类 号：R972.4[医药卫生—药品]