莫西沙星和左氧氟沙星治疗尿路感染的疗效比较  

Curative effect of moxifloxacin and levofloxacin on urinary tract infection and bacterial clearance

作　　者：何新洲[1] 崔波[1] 崔昕[1] 李进[1] He Xinzhou;Cui Bo;Cui Xin;Li Jin(Department of Urology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院泌尿外科,北京100053

出　　处：《感染．炎症．修复》2018年第1期31-34,共4页Infection Inflammation Repair

摘　　要：目的:探讨莫西沙星和左氧氟沙星对尿路感染的疗效及细菌清除率。方法:选取2015年10月-2017年10月首都医科大学宣武医院收治的尿路感染患者100例,按照随机数字表法随机分为观察组和对照组各50例,对照组患者使用左氧氟沙星口服治疗,观察组患者使用莫西沙星口服治疗,14 d为1个疗程。比较两组患者临床疗效、病原菌检出株数和细菌清除率,并对两组治疗前后免疫球蛋白相关指标和治疗过程中不良反应情况进行比较。结果:观察组治疗有效率(94.0%)高于对照组(80.0%,P<0.05)。治疗前观察组和对照组患者分别检出68、70株病原菌,治疗后分别检出6、19株细菌,观察组和对照组细菌清除率分别为91.17%和72.85%,两组比较差异有统计学意义(P<0.05)。观察组患者腰背部疼痛消失时间、尿路疼痛消失时间、尿濒尿急消失时间均明显少于对照组(P<0.05)。治疗前,两组患者IgA、IgG、IgM等指标无明显差异(P>0.05);治疗后观察组患者IgA、IgG、IgM等指标升高程度明显优于对照组(P<0.05)。观察组不良反应发生率(12.0%)和对照组(14.0%)比较,差异无统计学意义(P>0.05)。结论:莫西沙星对尿路感染的疗效优于左氧氟沙星,可明显提高患者细菌清除率,改善患者免疫球蛋白水平,且无不良反应增多现象,值得临床推广应用。Objective:To investigate the curative effect of moxifloxacin and levofloxacin on urinary tract infection and bacterial clearance.Methods:One hundred patients with urinary tract infection,admitted in the Department of Urology of Xuanwu Hospital during Oct.2015 to Oct.2017,were recruited in present study,and randomly divided into observation group and control group(50 each)according to the stochastic indicator method.Patients in control group received levofloxacin 0.1g orally,twice a day for 14 days,and in observation group received moxifloxacin 0.4 g orally,once a day for 14 days.The clinical efficacy,the strains of pathogens detected,levels of immunoglobulin(IgA,IgG,IgM)and the side-effects of the drugs were compared between the two groups.Results:The clinical efficient rate was higher in observation group(94.0%)than in control group(80.0%)with statistically significant difference(P<0.05).From observation group and control group,68 and 70 strains,respectively,of pathogenic bacteria were detected before treatment,while 6 and 19 strains,respectively,were detected after treatment;and the bacterial clearance were 91.17%and 72.85%,respectively,showing significant difference(P<0.05).The disappearance time of lumbar back pain,of urinary tract pain,and of frequent urination and urgency urine were significantly shorter in observation group than in control group(P<0.05).No significant difference existed in IgA,IgG and IgM between the two groups before treatment(P>0.05),while the levels of IgA,IgG and IgM were significantly higher in observation group than in control group after treatment(P<0.05).After treatment the incidence of side-effects showed no statistical significance between observation group(12.0%)and control group(14.0%,P>0.05).Conclusions:The curative effect of moxifloxacin is better than that of levofloxacin for urinary tract infections,with higher bacterial clearance,improved immunoglobulin levels and no more side-effects,so moxifloxacin is of worthy of further applic ation.

关 键 词：莫西沙星 左氧氟沙星 尿路感染 细菌清除率 

分 类 号：R691.3[医药卫生—泌尿科学]