内南五味子中木脂素类化学成分研究  

Lignan Constituents of Kadsura interior A. C. Smith

作　　者：张进[1] 黄嫚 李建光[1] 齐耀东[2] 刘海涛[2] 贾晓光[1] 张本刚[2] ZHANG Jin;HUANG Man;LI Jian-guang;QI Yao-dong;LIU Hai-tao;JIA Xiao-guang;ZHANG Ben-gang(Chinese Medicine Department,Xinjiang Medical University,Urumqi 830011,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China)

机构地区：[1]新疆医科大学中医学院,新疆乌鲁木齐830011 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中国现代中药》2018年第6期669-674,共6页Modern Chinese Medicine

基　　金：国家自然科学基金面上项目(81373913)

摘　　要：目的:研究内南五味子的化学成分。方法:采用硅胶柱色谱,羟丙基葡聚糖凝胶Sephadex LH-20、ODS及HPLC等多种色谱技术进行分离纯化,根据理化性质和波谱学方法鉴定化合物结构。结果:从内南五味子体积分数90%乙醇水提取物中分离得到了15个木脂素类化合物,分别为利卡灵A(1)、南五味子素(2)、异形南五味子丁素(3)、异形南五味子庚素(4)、8α-羟基松脂醇(5)、内南五味子素丙(6)、异形南五味子戊素(7)、扁核木醇(8)、阿里山五味子灵C(9)、苄基氧代南五味子醇(10)、松脂醇(11)、香豆木脂素(12)、川椒脂醇(13)、异形南五味子壬素(14)、二氢去氢二松柏醇(15)。结论:化合物1、5、7、8、10~15是首次从内南五味子中分离得到。Objective:To investigate the chemical constituents form stems of Kadsura interior.Methods:The compounds were isolated by various chromatographic techniques including silica gel column chromatography,Sephadex LH-20,ODS reverse phase column chromatography and reversed-phase HPLC.The structures were elucidated by physiochemical property and spectral analysis.Results:Fifteen compounds were isolated and identified as licarin A(1),kadsurin(2),heteroclitin D(3),heteroclitin G(4),8a-hydroxypinoresinol(5),interiorin C(6),heteroclitin E(7),prinsepiol(8),schiarisanrin C(9),benzoyl oxokadsuranol(10),pinoresinol(11),coumarinlignan(12),piperitol(13),heteroclitin I(14)and dihydrodehydrodiconiferyl alcohol(15),Conclusion:Compounds 1,5,7,8,10-15 were isolated from K.interior for the first time.

关 键 词：内南五味子 化学成分 木脂素 

分 类 号：R284.1[医药卫生—中药学]