喹诺酮类药物在肺结核治疗中的作用  

The Effect of Quinolones in the Treatment of Pulmonary Tuberculosis

作　　者：顾宏芳 施春林[1] GU Hongfang;SHI Chunlin(Infection Department,Rudong County People's Hospital,Nantong Jiangsu 226400,China)

机构地区：[1]南通市如东县人民医院传染科,江苏南通226400

出　　处：《中国继续医学教育》2018年第21期114-116,共3页China Continuing Medical Education

摘　　要：目的探究喹诺酮类药物在肺结核治疗中的作用。方法选取2016年4月—2018年3月在我院治疗的肺结核患者98例,对照组患者采取乙胺吡嗪利福异烟片联合护肝药物以及止咳化痰药物进行常规治疗,观察组患者在此基础上再使用左氧氟沙星,对比两组患者的临床疗效。结果观察组总有效率为95.92%,高于对照组(P<0.05);观察组患者不良反应发生率为2.04%,和对照组(4.08%)相比差异无统计学意义(P>0.05)。结论在常规用药治疗肺结核的基础上再联合使用喹诺酮类药物可以极大地提高药物疗效并且安全性高,值得临床参考。Objective To explore the role of quinolones in the treatment of pulmonary tuberculosis.Methods A total of 98 patients with pulmonary tuberculosis who were treated in our hospital from April 2016 to March 2018 were selected.The patients in the control group were treated with methimopyrazine and isoflavone tablets combined with liver protection drugs and cough and phlegm-removing drugs for routine treatment.The observation group patients on this basis,levofloxacin was used,the clinical efficacy of the two groups of patients was compare.Results The total effective rate in the observation group was 95.92%,which was significantly higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 2.04%,which was not significantly different from the control group(4.08%)(P>0.05).Conclusion The combination of fluoroquinolones on the basis of conventional treatment of pulmonary tuberculosis can greatly improve the efficacy of the drug and has high safety.

关 键 词：喹诺酮 左氧氟沙星 乙胺吡嗪利福异烟片 护肝 肺结核 疗效 

分 类 号：R521[医药卫生—内科学]