肿瘤Notch信号通路的研究进展  

Research progress of Notch signaling pathway in tumor

作　　者：王晓清[1] 袁国强[1] 潘亚文[1,2] WANG Xiao-qing;YUAN Guo-qiang;PAN Ya-wen(Institute of Neurology,the Second Hospital of Lanzhou University,Lanzhou 730030,China;Dept.of Neurosurgery,the Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院神经病学研究所,甘肃兰州730030 [2]兰州大学第二医院神经外科临床医学中心,甘肃兰州730030

出　　处：《基础医学与临床》2018年第7期1025-1028,共4页Basic and Clinical Medicine

基　　金：兰州市科技项目(2013-3-27)

摘　　要：Notch基因编码一类高度保守的细胞表面受体,决定胚胎发育和成熟组织中的细胞命运,是相邻细胞之间通讯进而调控细胞发育、增殖和凋亡的重要通路。多种肿瘤的发生与进展和Notch信号通路异常有关。针对不同肿瘤,有效调控靶向Notch的参与者与靶分子,对抗肿瘤治疗具有重要研究意义。Notch gene encodes a class of highly conserved cell surface receptors that determine the fate of cells in embryonic development and mature tissue,which is an important pathway of communication between adjacent cells,and then regulates of cell development,proliferation and apoptosis.The occurrence and progression of multiple tumors are associated with abnormal Notch signaling pathways.For different tumors,it is important significance for anti-tumor therapy to effectively regulate the Notch participants and target molecules.

关 键 词：NOTCH信号通路 肿瘤 异常 

分 类 号：R3[医药卫生—基础医学]