16α-羟基泼尼松龙的合成研究进展  

Review on the Research of the Synthesis of 16α-hydroxyprednisolone

作　　者：赵振国[1] 吴彩玲 杨萍 陈琳琳[1] 曹宏伟[1] Zhao Zhenguo;Wu Cailing;Yang Ping;Chen Linlin;Cao Hongwei(Shandong Medicine Technician College,Department of Biological Engineering,Taian 271000,China;Jewim Pharmaceutical(Shandong)Co.,Ltd.,Quality Research Department,Taian 271000,China)

机构地区：[1]山东医药技师学院生物工程系,山东泰安271000 [2]山东京卫制药有限公司质量研究室,山东泰安271000

出　　处：《山东化工》2018年第12期58-59,62,共3页Shandong Chemical Industry

摘　　要：16α-羟基泼尼松龙是用于制备布地奈德、环索奈德和地索奈德等甾体抗炎药的重要中间体,市场前景非常广阔。本文综述了16α-羟基泼尼松龙的合成方法,并简要分析了各合成方法的优缺点。16α-hydroxyprednisolone are the key intermediates for the preparation of budesonide,ciclesonide,desonide and other steroidal anti-inflammatory drugs,and has capacious market future.This paper reviews the synthesis of 16α-hydroxyprednisolone,and a brief analysis of the advantages and disadvantages of each method of synthesis.

关 键 词：16α-羟基泼尼松龙 合成 进展 

分 类 号：TQ467[化学工程—制药化工]