ICP-MS法测定注射用牡荆素铅、镉、砷、汞、铜的含量  

Determination of Pb,Cd,As,Hg and Cu in Vitexin Injection by ICP-MS

作　　者：徐茂红[1] 邵旭[2] 牛海军[2] 李晓亮[2] 李光辉 XU Maohong;SHAO Xu;NIU Haijun;LI Xiaoliang;LI Guanghui(Department of Pharmacy,West Anhui Health Vocational College,Lu’an 237000,China;Hefei Qi Xing Medicine and Technology Co.Ltd,Hefei 230088,China)

机构地区：[1]皖西卫生职业学院药学系,安徽六安237000 [2]合肥七星医药科技有限公司,安徽合肥230088

出　　处：《安徽科技学院学报》2018年第2期90-94,共5页Journal of Anhui Science and Technology University

基　　金：国家科技重大专项(2017ZX09301025)

摘　　要：目的:测定注射用牡荆素中的铅、镉、砷、汞、铜等5种重金属元素的含量,探讨牡荆素注射剂重金属的质量控制方法。方法:经微波消解后的注射用牡荆素样品,加入铅、镉、砷、汞、铜等内标元素,ICPMS(电感耦合等离子体质谱)法测定样品中铅、镉、砷、汞、铜的含量。结果:铅、镉、砷、汞、铜的检出限分别为0.4、0.03、0.09、0.04及0.05ng/mL;且线性关系良好(r>0.998);铅、镉、砷、汞、铜回收率分别为97.8%、97.2%、104.0%、91.2%和92.8%。结论:本方法操作简便、灵敏度高、专属性好,适用于注射用牡荆素中铅、镉、砷、汞、铜的质量控制。Objective:To determine the content of Pb,Cd,As,Hg and Cu in Vitexin injection,and to study the quality control method of heavy metals.Methods:Using ICP-MS method to determine the content of Pb,Cd,As,Hg and Cu in Vitexin injection,and the samples were digested by microwave.Results:The results showed that the detection limit ranges of Pb,Cd,As,Hg and Cu in Vitexin injection ware 0.4,0.03,0.09,0.04 and 0.05 ng/mL respectiuely,the method had good linear correlation(r>0.998),the recoveries of Pb,Cd,As,Hg and Cu in Vitexin injection were 97.8%,97.2%,104.0%,91.2%and 92.8%.Conclusions:The method is simple and has good sensitivity and specificity.The method can be used for the contents determination of Pb,Cd,As,Hg and Cu in Vitexin injection.

关 键 词：注射用牡荆素 电感耦合等离子体质谱法 重金属 

分 类 号：R917[医药卫生—药物分析学]