IDMs合并心肌损害对GPBB的影响及其意义  

Serum GPBB level and its clinical significance in infants of diabetic mothers

作　　者：魏继红[1] 姬静璐[1] 谭笑 王欣[1] 张欢欢[1] 柏金秀[1] Ji-hong Wei;Jing-lu Ji;Xiao Tan;Xin Wang;Huan-huan Zhang;Jin-xiu Bai(Department of Pediatrics,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China)

机构地区：[1]河北大学附属医院儿科,河北保定071000

出　　处：《中国现代医学杂志》2018年第20期57-60,共4页China Journal of Modern Medicine

基　　金：河北省临床医学优秀人才培养项目(No:361007)

摘　　要：目的研究糖原磷酸化酶同功酶脑型(GPBB)在糖尿病母亲婴儿(IDMs)合并心肌损害时的变化及其意义。方法选取2014年1月-2014年12月于河北大学附属医院入住新生儿病房的132例IDMS为研究对象,于出生后3、6、12和24 h分别检测血清GPBB浓度。比较无心肌损害组、心肌损害组及对照组各时间点GPBB的水平变化,分析GPBB与围产高危因素的关系。结果心肌损害组血清GPBB水平高于无心肌损害组和对照组(P<0.05)。母亲孕期血糖控制不良、妊娠期糖尿病病程长(≥3个月)、新生儿低血糖对GPBB水平的影响较大(P<0.05)。结论 GPBB可作为检测IDMs发生心肌损害的早期敏感指标。Objective To detect the serum level of glycogen phosphorylase isozyme BB(GPBB)in infants of diabetic mothers(IDMs)with myocardial damage and discuss its clinical significance.Methods Totally 132 IDMs who were admitted to the Neonatal Ward in the Affiliated Hospital of Hebei University from January to December 2014 were selected as the study subjects.Their blood GPBB level was detected at 3,6,12 and 24 h after birth,and compared with the control group.Of the 132 IDMs,40 were diagnosed as myocardial damage(myocardial damage group)and 92 did not have myocardial damage(non-myocardial damage group).And the GPBB levels were compared among myocardial damage group,non-myocardial damage group and control group at each time point.The correlations between GPBB level and the perinatal risk factors were also discussed.Rusults The GPBB level of the myocardial damage group was higher than those of the non-myocardial damage group and the control group at 3,6,12 and 24 h after birth(P<0.05).GPBB level was greatly affected by poor control of serum glucose in the mothers during pregnancy,long course of gestational diabetes(≥3 months),and neonatal hypoglycemia(P<0.05).Conclusions GPBB could be used as an early sensitive marker of myocardial damage in IDMs.

关 键 词：糖原磷酸化酶同功酶脑型 糖尿病母亲婴儿 心肌损伤 

分 类 号：R587.1[医药卫生—内分泌]