维生素E对膝骨性关节炎的疗效分析  

Effect of vitamin E on knee osteoarthritis

作　　者：华仲森[1] 陈之青[1] 俞雷钧[2] Zhong-sen Hua;Zhi-qing Chen;Lei-jun Yu(Department of Orthopedics,the Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China;Department of Orthopedics and Traumatology,Tongde Hospital of Zhejiang Province,Hangzhou,Zhejiang 310012,China)

机构地区：[1]杭州师范大学附属医院骨科,浙江杭州310015 [2]浙江省立同德医院骨伤科,浙江杭州310012

出　　处：《中国现代医学杂志》2018年第20期61-64,共4页China Journal of Modern Medicine

基　　金：浙江省科技厅合作研发和成果转化项目(No:2014F50005)

摘　　要：目的探讨维生素E对膝骨性关节炎患者氧化应激水平和临床疗效的影响。方法前瞻性收集2016年1月-2016年12月该院收治的膝骨性关节炎患者,分为观察组和对照组,各40例。两组患者均给予常规治疗。在此基础上,观察组口服维生素E,总疗程6个月。观察两组氧化应激反应和临床疗效。结果两组患者治疗前谷胱甘肽过氧化物酶、超氧化物歧化酶水平比较,差异无统计学意义(P>0.05)。治疗后6个月,观察组谷胱甘肽过氧化物酶和超氧化物歧化酶[(122.73±25.65)μmol/L和(104.82±18.94)μ/ml]较对照组[(145.92±26.74)μmol/L和(122.68±19.84)u/ml]降低(P<0.05)。两组患者治疗前疼痛积分、关节僵硬评分、日常活动积分,以及西部安大略麦克马斯特大学骨关节炎指数可视化量表(WOMAC)总分比较,差异无统计学意义(P>0.05)。治疗后6个月,观察组患者疼痛积分、关节僵硬评分、日常活动积分及WOMAC总分较对照组降低(P<0.05)。两组患者治疗前Lysholm膝关节运动功能评分比较,差异无统计学意义(P>0.05)。治疗后6个月,观察组患者Lysholm膝关节运动功能评分[(75.21±10.85)分]较对照组增加[(66.48±10.44)分](P<0.05)。结论维生素E可以降低膝骨性关节炎患者氧化应激水平,改善患者关节功能。Objective To investigate the effect of vitamin E on the level of oxidative stress and the clinical efficacy in patients with osteoarthritis of the knees.Methods The patients with osteoarthritis of the knees in our hospital were prospectively collected from January to December 2016,and divided into an observation group and a control group with 40 cases in each group.The patients of both groups received routine treatment.And the patients in the observation group received additional oral administration of vitamin E.The whole course was 6 months.The oxidative stress reaction and clinical efficacy were compared between the two groups.Results There was no significant difference in the level of glutathione peroxidase or superoxide dismutase between the two groups before treatment(P>0.05).After 6-month treatment,the levels of glutathione peroxidase[(122.73±25.65)vs.(145.92±26.74)μmol/L,P<0.05]and superoxide dismutase[(104.82±18.94)vs.(122.68±19.84)u/ml,P<0.05]decreased in the observation group compared with the control group.There was no significant difference in pain score,joint stiffness score,daily activity score or total score of Western Ontario MacMaster University Osteoarthritis index(WOMAC)between the two groups before treatment(P>0.05).After 6-month treatment,when compared with the control group,the patients in the observation group got decreased pain score,joint stiffness score,daily activity score and total score of WOMAC(P<0.05).There was no statistical difference in Lysholm knee motor function score between the two groups before treatment(P>0.05).After treatment for 6 months,the score of Lysholm knee motor function in the observation group was higher than that in the control group[(75.21±10.85)vs.(66.48±10.44),P<0.05].Conclusions Vitamin E can reduce the level of oxidative stress in the patients with osteoarthritis of the knees and improve the joint function of the patients.

关 键 词：维生素E 骨性关节炎 氧化应激 临床疗效 

分 类 号：R684.3[医药卫生—骨科学]