早期糖尿病视网膜病变黄斑区视神经节细胞复合体厚度的临床研究  

Alterations of macular ganglion cell complex thickness in early diabetic retinopathy

作　　者：戴馨[1] 武海军[2] Dai Xin;Wu Haijun(Heze Medical College;Heze Municipal Hospital,Shandong 274000,China)

机构地区：[1]菏泽医学专科学校眼科学暨眼视光技术教研室,274000 [2]菏泽市立医院眼科

出　　处：《临床眼科杂志》2018年第3期197-200,共4页Journal of Clinical Ophthalmology

基　　金：山东省医药卫生科技发展计划项目(编号:2016WSA17005)

摘　　要：目的比较糖尿病患者与正常对照组黄斑区视网膜神经节细胞复合体(GCC)厚度,评估其在早期糖尿病视网膜病变(DR)诊断和随访中的临床价值。方法本研究纳入正常成年人110例(110只眼)(正常对照组)、无明显视网膜病变糖尿病患者(NDR组)76例(76只眼)和轻度非增生性视网膜病变糖尿病患者(NPDR组)50例(50只眼),采用RTVUE 100-2型相干光断层扫描检查仪对黄斑区视网膜进行扫描,测量总体平均厚度(GCCAvg)、上方平均厚度(GCC-Sup)、下方平均GCC厚度(GCC-Inf)、整体丢失容积(GLV)与局部丢失容积(FLV)。分析比较正常对照组和糖尿病组GCC厚度差异。对数据进行单因素方差分析。结果正常对照组GCC-Avg为(117.76±1.20)μm,GCC-Sup为(117.29±4.90)μm,GCC-Inf为(113.26±1.63)μm,NDR组GCC-Avg为(103.31±2.13)μm,GCC-Sup为(103.21±1.37)μm,GCC-Inf为(102.44±2.35)μm,NPDR组GCC-Avg为(94.64±1.52)μm,GCC-Sup为(95.50±1.44)μm,GCC-Inf为(94.70±1.01)μm,糖尿病组各区GCC厚度均较正常对照组变薄,3组间比较差异均有统计学意义;3组GLV分别为(3.58±0.58)%、(4.93±0.48)%、(7.62±0.34)%,FLV分别为(2.18±0.48)%、(4.08±0.74)%、(3.45±0.60)%,3组间比较差异有统计学意义,NPDR、NDR组比较差异无统计学意义(P=0.133)。结论糖尿病患者黄斑各区GCC厚度均变薄,可用于糖尿病的检查和随访。Objective To investigate the macular ganglion cell complex(GCC)thickness in both diabetes patients and normal subjects and to evaluate the clinical value of perimetry in diagnosis and following of the diabetic retinopathy(DR).Methods The control group consisted of 110 normal age-matched subjects(110 eyes).Diabetes patients were divided into NDR group(76 eyes)and NPDR group(50 eyes).The macular GCC thickness was measured with optical coherence tomography(OCT).The examination included average thickness of GCC(GCC-Avg),superior(GCC-Sup)and inferior thickness of GCC(GCC-Inf),focal loss of volume(FLV)and general loss of volume(GLV).The difference in GCC thickness was analyzed among three groups.The collected data were analyzed with One-way ANOVA.Results The GCC-Avg was 117.76±1.20μm in normal subjects,103.31±2.13μm in NDR patients and 94.64±1.52μm in DR patients.GCC-Sup was 117.29±4.90μm,103.21±1.37μm and 95.50±1.44μm respectively.GCC-Inf values was 113.26±1.63μm,102.44±2.35μm and 94.70±1.01μm respectively.The differences in GCC-Avg,GCC-Sup and GCC-Inf were statistically significant.The GLV was 3.58±0.58%,4.93±0.48%and 7.62±0.34%(P<0.001),and FLV was 2.18±0.48%,4.08±0.74%and 3.45±0.60%.There was no significant difference between NDR and NPDR patients(P=0.133).Conclusions The macular GCC in diabetes patients is thinner than that of normal eyes,and the thickness is a good diagnostic parameter.

关 键 词：神经节细胞复合体 相干光断层扫描 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌]