盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响  

Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure

作　　者：李铎[1] 王建华[1] LI Duo;WANG Jian-hua(Department of Cardiology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院心内科,黑龙江佳木斯154002

出　　处：《医学信息》2018年第10期126-128,共3页Journal of Medical Information

摘　　要：目的探讨盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者的氧化应激、心肌功能的影响。方法选择我院心内科2016年6月~2017年6月80例冠心病伴心力衰竭患者,按照随机数字表法分为传统组与辅助组,每组40例,传统组患者给予常规治疗,辅助组患者在常规治疗基础上给予盐酸曲美他嗪片辅助治疗,对比两组患者治疗后LVEF、SO、LVESD、LVEDD、MDA水平。结果辅助组患者治疗后LVEF(58.1±7.5)%、SOD(120.2±15.8)U/ml较传统组(51.2±6.5)%、(84.2±12.4)U/ml升高,LVESD(44.8±4.2)mm、LVEDD(31.2±3.3)mm、MDA(6.2±1.3)μmol/L较传统组(48.2±4.6)mm、(35.4±3.5)mm、(8.6±1.5)μmol/L降低,差异有统计学意义(P<0.05)。结论盐酸曲美他嗪片辅助治疗冠心病伴心力衰竭患者可改善患者氧化应激状况,提升患者心肌功能。Objective To investigate the effects of adjuvant trimetazole hydrochloride on oxidative stress and myocardial function in patients with coronary heart disease complicated with heart failure.Methods From June 2016 to June 2017,80 patients with coronary heart disease complicated with heart failure in our hospital were divided into two groups:the traditional group(40 cases)and the auxiliary group(40 cases).The patients in the traditional group were treated with routine therapy.The patients in the adjuvant group were given trimetazidine hydrochloride on the basis of routine treatment,the levels of LVEF,SO,LVESD,LVEDD and MDA were compared between the two groups after treatment.Results After treatment,LVEF(58.1±7.5)%and SOD(120.2±15.8)U/ml in the adjuvant group were higher than those in the traditional group(51.2±6.5)%and(84.2±12.4)U/ml,and the LVESD was(44.8±4.2)mm.LVEDD(31.2±3.3)mm,MDA(6.2±1.3)μmol/L decreased compared with the traditional group(48.2±4.6)mm,(35.4±3.5)mm,(8.6±1.5)μmol/L,the difference was statistically significant(P<0.05).Conclusion Trimetazidine hydrochloride tablets adjuvant treatment of coronary heart disease complicated with heart failure can improve the patient's oxidative stress,improve myocardial function.

关 键 词：冠心病 心力衰竭 盐酸曲美他嗪片 氧化应激 心肌功能 

分 类 号：R541.4[医药卫生—心血管疾病] R541.6[医药卫生—内科学]