4-67 miR-300 Modulates the Cellular Radiosensitivity Through Targeting p^53 in Human Non-small Cell Lung Cancer A549 Cells  

作　　者：He Jinpeng Wei Wenjun Feng Xiu Hua Junrui Lu Zhiwei Jin Liangliang Ding Nan Zhang Yanan Li He Wang Jufang 

机构地区：[1]不详

出　　处：《IMP & HIRFL Annual Report》2016年第1期193-194,共2页中国科学院近代物理研究所和兰州重离子研究装置年报（英文版）

摘　　要：microRNAs(miRNAs)perform crucial roles in mediation of the cellular radiosensitivity by influencing DNA damage repair,cell cycle checkpoint,apoptosis,radio-related signal transduction pathway and microenvironment[1-3].Our previous study have suggested that miR??300,whose expression is correlated positively with the cellular resistance to chemotherapy drug cis-platin in human ovarian cancer cells[4],is involved in the cellular response to the DNA damages induced by ionizing radiation[5].However,the underlying molecular mechanisms remain unclear.

分 类 号：O4[理学—物理]