噬菌体与宿主细菌的攻防机制  

Defense and Anti-defense Mechanisms of Bacteriophages and Host Bacteria

作　　者：张庆[1] 商延 朱见深 刘晓文 宋胜敏 柳林 由佳 朱应民 齐静[1,3] 李璐璐 胡明[1] 戴美学[3] 刘玉庆[1,2,3] Zhang Qing;Shang Yan;Zhu Jianshen;Liu Xiaowen;Song Shengmin;Liu Lin;You Jia;Zhu Yingmin;Qi Jing;Li Lulu;Hu Ming;Dai Meixue;Liu Yuqing(Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences/Key Laboratory of Animal Disease Prevention and Breeding,Jinan 250100,China;School of Life Sciences,Shandong University,Jinan 250100,China;School of Life Sciences,Shandong Normal University,Jinan 250014,China;Yantai Animal Husbandry and Veterinary Bureau,Yantai 264000,China)

机构地区：[1]山东省农业科学院畜牧兽医研究所/山东省畜禽疫病防治与繁育重点实验室,山东济南250100 [2]山东大学生命科学学院,山东济南250100 [3]山东师范大学生命科学学院,山东济南250014 [4]烟台市畜牧兽医局,山东烟台264000

出　　处：《山东农业科学》2018年第7期48-54,共7页Shandong Agricultural Sciences

基　　金：国家自然科学基金项目(31672609);国家自然科学基金国际合作与交流项目(813611138021;81661138006);国家重点研发计划项目(2016YFD0501301;2018YFD0500502);山东省现代农业产业体系家禽创新团队环境控制岗位专家(SDAIT-13-011-09);山东省自然科学基金项目(ZR2014CP021)

摘　　要：噬菌体是侵袭细菌的病毒,也是病毒中最普遍、分布最广的类群。为了防止噬菌体侵染,细菌进化出多种多样的防御机制;而为了突破这些防御机制,噬菌体也进化得到了相对应的反制策略。本文即综述了这一领域的研究进展,有助于理解噬菌体与宿主细菌的共存共进化机制,合理利用噬菌体。Bacteriophage,the virus of bacteria,is the world’s largest and most abundant organism of virus.On one hand,bacteria have developed various defense mechanisms to prevent phage infection,and on the other hand,phages have also evolved corresponding countermeasures to break through these defense mechanisms.In this paper,the research progress in this field was reviewed to understand the co-evolution mechanism between phage and host bacteria,so as to facilitate the rational use of phage.

关 键 词：噬菌体 细菌宿主 防御机制 反防御机制 

分 类 号：S852.6[农业科学—基础兽医学]