胃癌中lncRNAs的研究进展  

Research Progress of lncRNAs in Gastric Cancer

作　　者：尹晓华 刘重元[1] 黄琳[3] 罗苇如 肖玄 张志伟[1] YIN Xiao-hua;LIU Zhong-yuan;HUANG Lin;LUO Wei-ru;XIAO Xuan;ZHANG Zhi-wei(Institute of Oncology,Key Laboratory of Tumor Cell and Molecular Pathology,School of Medicine,Nanhua University,Hengyang 421001,Hunan;China;Department of Biochemistry,College of Basic Medicine,Xiangnan University,Chenzhou 423000,Hunan,China;Department of Pediatrics,Shaoyang Medical College Affiliated Hospital,Shaoyang 422000,Hunan,China;Department of Clinical Medical Excellence,School of Medicine,Nanhua University,Hengyang 421001,Hunan,China)

机构地区：[1]南华大学医学院肿瘤研究所/肿瘤细胞与分子病理学湖南省重点实验室,湖南衡阳421001 [2]湘南学院基础医学院生物化学教研室,湖南郴州423000 [3]邵阳医学高等专科学校附属医院儿科,湖南邵阳422000 [4]南华大学医学院,湖南衡阳421001

出　　处：《医学信息》2018年第3期10-12,共3页Journal of Medical Information

基　　金：湖南省高校创新平台基金(编号:12K094、13K083);湖南省研究生科研创新项目(编号:CX2016B478);南华大学博士科研启动基金(编号:2016XQD21);南华大学大学生创新项目(编号:2016NH055XJXZ)

摘　　要：胃癌是一种我国最常见的消化道恶性肿瘤,严重威胁人们健康与生命。阐明胃癌发病的分子机制及获得新的分子靶点对胃癌防治尤为重要。长链非编码RNAs的发现对深入阐明胃癌发病的分子机制及发现新的分子标志物提供了可能。本文对lncRNAs在胃癌中的表达以及对胃癌的生长增殖、转移、耐药与预后等研究进行综述。Gastric cancer is one of the most common gastrointestinal malignancies in our country,which seriously threatens people's health and life.To clarify the molecular mechanism of gastric cancer and obtain new molecular targets for the prevention and treatment of gastric cancer is particularly important.The discovery of long non-coding RNAs has made it possible to further elucidate the molecular mechanism of gastric cancer and find new molecular markers.In this paper,the expression of lncRNAs in gastric cancer and the growth,proliferation,metastasis,drug resistance and prognosis of gastric cancer were reviewed.

关 键 词：胃癌 lncRNAs 生物标志物 表达调控 

分 类 号：R318[医药卫生—生物医学工程]