α_1-抗胰蛋白酶与维吾尔族慢性阻塞性肺疾病的相关性分析  

Correlation Analysis of α_1-antitrypsin and Uygur Chronic Obstructive Pulmonary Disease

作　　者：钟雪梅[1] 李黎[1] 米热班.热夏提 任杰[1] 排尔达 木克热木.亚森 ZHONG Xue-mei;LI Li;Mirban·rixat;REN Jie;Patar;Mukaram·yasin(Department of Respiratory and Critical Care Medicine,First People's Hospital of Kashi Prefecture,Kashi 844000,Xinjiang,China)

机构地区：[1]新疆喀什地区第一人民医院呼吸与危重症医学科,新疆喀什844000

出　　处：《医学信息》2018年第2期67-70,共4页Journal of Medical Information

摘　　要：目的探讨α1-抗胰蛋白酶水平以及其基因位点rs1243166多态性与喀什地区维吾尔族慢性阻塞性肺疾病的关系。方法采集429例维吾尔族人群血标本,其中227例COPD患者作为病例组,202例健康维吾尔族体检者作为对照组,利用α1-抗胰蛋白酶检测试剂盒检测α1-抗胰蛋白酶水平,Mass ARRAYi PLEX单碱基延伸技术进行基因检测,对最终检测结果进行χ2检验,采用单因素的logistic回归对不同基因型进行危险因素分析。结果病例组和对照组α1-抗胰蛋白酶水平,差异有统计学意义(P<0.05),Rs1243166位点基因型和等位基因频率在病例组和对照组中分布比较,有统计学意义(P<0.05)。人群携带rs1243166-GG基因型患COPD的风险是携带rs1243166-AA基因型的2.039倍,携带rs1243166-GA基因型的人群患COPD的风险是携带rs1243166-AA基因型人群的1.875倍。结论α1-抗胰蛋白酶与COPD相关,rs1243166基因位点与COPD的易感性有关,人群携带rs1243166-GG基因型和rs1243166-GA基因型有较高的患病风险。Objective To investigate the relationship betweenα1-antitrypsin level and rs1243166 polymorphism and Uygur chronic obstructive pulmonary disease in Kashgar region.Methods Blood samples were collected from 429 Uygur people,including 227 COPD patients as the case group and 202 healthy Uygur people as the control group.Usingα1-antitrypsin detection kit to detectα1-antitrypsin level,MassARRAYiPLEX single base extension technique was used to detect the gene,and the final results were tested by X2.Single factor logistic regression was used to analyze the risk factors of different genotypes.Results The levels ofα1-antitrypsin in the case group and the control group were significantly different(P<0.05).The genotypes and allelic frequencies of Rs1243166 locus were compared between the case group and the control group.There was a statistically significant difference(P<0.05).The risk of people carrying rs1243166-GG genotype with COPD is 2.039 times of carrying rs1243166-AA genotype,the risk of carrying rs1243166-GA genotype COPD prevalence is 1.875 times of carrying rs1243166-AA genotype groups.Conclusionα1-antitrypsin is associated with COPD and rs1243166 locus is associated with COPD susceptibility.People with rs1243166-GG genotype and rs1243166-GA genotype have a higher prevalence.

关 键 词：Α1-抗胰蛋白酶 单核酸基因多态性 维吾尔族 慢性阻塞性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]