双膦酸盐类药物治疗骨质疏松症药物假期的研究进展  

Research progress of bisphosphonate drug holiday in treatment of osteoporosis

作　　者：郝鹏飞 霍建忠 季兴华 HAO Peng-Fei;HUO Jian-Zhong;JI Xing-Hua(Department of Orthopedics,Shanxi Dayi Hospital,Shanxi Medical University,Taiyuan 030032,China)

机构地区：[1]山西医科大学附属大医院骨科,太原030032

出　　处：《中华老年多器官疾病杂志》2018年第7期541-544,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：山西省科技厅科技攻关项目(20150313012-1)~~

摘　　要：骨质疏松症是绝经后妇女和老年男性的常见病。双膦酸盐是治疗骨质疏松症的一线药物,其具有残留作用,在用药结束后仍可发挥抑制破骨细胞功能的作用。尽管双膦酸盐类药物的用药安全性已被证实,但长期使用可出现一些潜在不良反应,包括非典型性股骨骨折及双膦酸盐性下颌骨坏死等,这已引起越来越多专家的注意。施行药物假期的目的是在尽可能保证骨质疏松患者骨量及骨密度的情况下减少使用双膦酸盐类药物的使用,以期将其长期使用可能带来的不利因素降到最低。在药物假期期间,应合理监测相关骨指标,如有骨密度值明显降低或者新发骨折,即应立刻开始重新治疗。Osteoporosis is a common disease in postmenopausal women and older men.Bisphosphonates,the first-line drug for the osteoporosis,have a residual effect and can continue to exert a persistent inhibitory effect on osteoclast function after therapy is stopped.Although bisphosphonates are proven to be generally safe,concerns have emerged about potential adverse effects related to long-term use,such as atypical femoral fractures and osteonecrosis of the jaw.The purpose of drug holiday is to reduce the use of bisphosphonates with the guarantee of good bone mass and bone mineral density for osteoporosis patients,so to minimize the possible adverse effects of long-term use.During the drug holiday,relevant bone indexes should be properly monitored,and the therapy should be restarted immediately if there is a significant decrease in bone mineral density or new fractures.

关 键 词：骨质疏松 双膦酸盐 药物假期 

分 类 号：R681[医药卫生—骨科学]