低氧对BDNF和TrkB受体及其信号通路影响的研究进展  

Progress on Effects of Hypoxia on BDNF/TrkB Receptors and Signaling Pathways

作　　者：吴晓东 姜树原[1,2,3] 贾小娥 巴德仁贵 谢伟 邵国[1,2,3] WU Xiao-dong;JIANG Shu-yuan;JIA Xiao-e;BADE Rengui;XIE Wei;SHAO Guo(Biomedicine Research Center,Neuroscience Institute,Baotou Medical College,Baotou,Inner Mongolia,014040,China;Inner Mongolia Key laboratory of Hypoxic Translational Medicine,Baotou Medical College,Baotou,Inner Mongolia,014040,China;The key laboratory of Beijing,Hypoxic Preconditioning Translational Medicine,Xuanwu Hospital,Capital Medical University,Beijing,100053,China)

机构地区：[1]包头医学院生物医学研究中心与神经科学研究所,内蒙古包头014040 [2]包头医学院内蒙古自治区低氧转化医学重点实验室,内蒙古包头014040 [3]首都医科大学宣武医院低氧适应转化医学北京市重点实验室,北京100053

出　　处：《动物医学进展》2018年第8期101-105,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(81550038;81360316;81460283;81660307);内蒙古自然科学基金项目(2015BS0807;2015BS0801;2014MS0810;2016MS(LH)0307);内蒙古自治区高等学校"青年科技英才支持计划"项目(NJYT-18-B26);包头医学院博士科研启动基金项目(BSJJ201623;BSJJ201632);包头医学院科学研究基金项目(BYJJ-YF 201606)

摘　　要：探析了急性低氧损伤与适度低氧或低氧预适应(HPC)神经保护作用的相关机制及其涉及的信号通路研究进展,回顾了脑源性神经营养因子(BDNF)、酪氨酸激酶受体B(TrkB)及BDNF/TrkB信号通路在神经生理及神经病理过程中的作用,并对急性低氧与低氧预适应分别影响BDNF、TrkB受体的表达和BDNF/TrkB信号通路的相关途径与机制进行了归纳。通过总结了解到低氧具有双重作用,既有严重缺氧导致损伤,又有适度低氧或低氧预适应对机体有益的保护作用,阐明其调节机制具有一定的参考价值。This paper explored the mechanism of hypoxia injury and hypoxia preconditioning neuroprotective function,and the progress on signal pathways involved in hypoxia injury and hypoxia preconditioning neuroprotective function,reviewed the latest advances in the role of BDNF,TrkB receptors and BDNF/TrkB signal pathways in neurophysiological and neuropathological processes.This paper also summarized the mechanism of BDNF,TrkB receptor expression affected by hypoxia and hypoxia preconditioning,respectively.It was concluded that hypoxia has dual effects,both severe hypoxia leads to injury,and moderate hypoxia or hypoxic preconditioning is beneficial to the organism.Therefore,it will be more valuable to clarify its regulatory mechanism.

关 键 词：低氧/低氧预适应 脑源性神经营养因子 酪氨酸激酶受体B 信号通路 神经保护 

分 类 号：S852.33[农业科学—基础兽医学]