G6PD缺乏新生儿高胆红素血症的预后相关风险因素分析及临床护理对策  

Analysis of Prognostic Risk Factors and Nursing Strategies for Hyperbilirubinemia in Term Infants with G6PD Defect

作　　者：卢冬梅[1] 周静 蒋琳 LU Dongmei;ZHOU Jing;JIANG Lin(Chengdu Longquanyi District Maternal and Child Health Hospital,Chengdu 610100,China)

机构地区：[1]成都市龙泉驿区妇幼保健院,四川成都610100

出　　处：《中外医学研究》2018年第19期13-15,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:新生儿高胆红素血症是新生儿住院和再住院的最常见原因,高胆红素血症新生儿后遗症风险高,本研究旨在探讨新生儿高胆红素血症预后的危险因素。方法:对笔者所在医院收治的80例高胆红素血症新生儿开展为期2年的回顾性研究,将其分为葡萄糖-6-磷酸脱氢酶(G6PD)缺乏组(试验组)与G6PD正常组(对照组),比较分析临床相关危险因素。结果:试验组首次发现黄疸时间早于对照组,差异有统计学意义(P<0.05);两组神经行为学评分比较,差异无统计学意义(P>0.05)。试验组中9例(22.5%)患儿脑干听觉诱发电位检测结果异常,对照组仅有1例(2.5%)检测结果异常,两组比较差异有统计学意义(P<0.05)。试验组新生儿黄疸消退时间为(7.23±1.67)d,长于对照组的(5.12±1.40)d,差异有统计学意义(P<0.05)。结论:G6PD缺乏是影响新生儿高胆红素血症预后的危险因素之一。临床护理中应密切关注该类患儿,加强对G6PD缺乏症新生儿护理工作,对总胆红素评估并进行积极管理,降低后遗症的发生率。Objective:Neonatal hyperbilirubinemia continued to be the most common cause of neonatal hospitalization and rehospitalization.The risk of neonatal sequelae of hyperbilirubinemia was high.This study was designed to investigate glucose-6-phosphate dehydrogenase(G6PD)lacks risk factors for neonatal hyperbilirubinemia.Method:A 2-year prospective observational study treated in our hospital was conducted on 80 neonates with bilirubinemia.They were divided into glucose-6-phosphate dehydrogenase(G6PD)deficiency group(test group)and G6PD normal group(control group).Result:The first found of the jaundice time in the test group was earlier than that in the control group,the difference was statistically significant(P<0.05).And there was no statistical difference in neurobehavioral score between the two groups(P>0.05).The results of brainstem auditory evoked potential abnormal was 9 cases(22.5%)in the test group,and only 1 case(2.5%)in the control group,and the difference was statistically significant(P<0.05).The neonatal jaundice subsided time in the test group was(7.23±1.67)d,longer than(5.12±1.40)d in the control group,the difference was statistically significant(P<0.05).Conclusion:G6PD deficiency is one of the risk factors for the prognos of neonatal hyperbilirubinemia.Clinical care should pay close attention to this type of neonates,assess and actively manage total bilirubin,reduce the incidence of sequelae.

关 键 词：高胆红素血症 葡萄糖-6-磷酸脱氢酶 危险因素 新生儿 听力损伤 黄疸 

分 类 号：R473.72[医药卫生—护理学]