流行性乙型脑炎与其他病毒性脑炎的临床特征对比分析  

Comparative Analysis of Clinical Features of Japanese Encephalitis and Other Viral Encephalitis

作　　者：王丽恒[1] 李梦竹 夏曦[1] 姚亚希 蒋红[1] 曾跃[1] WANG Liheng;LI Mengzhu;XIA Xi(The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院,四川南充637000 [2]川北医学院

出　　处：《中外医学研究》2018年第19期15-18,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：川北医学院校级科研发展计划项目(项目编号:CBY17-A-YB37)

摘　　要：目的:分析35例流行性乙型脑炎与38例除乙脑外的其他病毒性脑炎的流行病学及临床资料,了解两种疾病临床特征的差异性,以提高临床医师对乙脑及其他病毒性脑炎的认识和诊疗水平。方法:选取2016年6月-2017年9月川北医学院附属医院收治的流行性乙型脑炎患儿(35例)和其他病毒性脑炎患儿(38例)的流行病学及临床资料,并对该资料进行分析。结果:乙脑与其他病毒性脑炎均主要集中在6岁以下儿童,乙脑发病月份均在7~8月,88.57%患儿来自农村,其他病毒性脑炎全年均有发病,其中5月、6月、12月病例数较多,农村、城市发病无明显差异;乙脑患儿血白细胞总数及中性粒细胞百分比明显高于其他病毒性脑炎组,比较差异均有统计学意义(P<0.05);两组患儿血红蛋白水平及AST、LDH、肌酐水平比较差异均无统计学意义(P>0.05);乙脑组脑脊液细胞数及蛋白质水平均明显高于其他病毒性脑炎组,比较差异均有统计学意义(P<0.05);乙脑患儿治愈率为40.00%,无效/死亡率为14.29%,出院时多名患儿有不同程度的功能障碍,其他病毒性脑炎患儿治愈率为71.05%,无效/死亡率为0,出院时仅少数患儿有轻微的功能障碍。结论:流行性乙型脑炎与其他病毒性脑炎的病原体、地域分布、发病时间、传播途径、预防方式、病情轻重及预后等均有不同,患儿的临床表现不具有特异性,诊断上需同时结合发病季节、实验室检查及特异性抗体检查明确,多数乙脑患儿较其他病毒性脑炎患儿病情重、死亡率高、预后差。Objective:The epidemiological and clinical data of 35 cases of Japanese encephalitis(JE)and 38 cases of viral encephalitis except JE were analyzed to understand the differences in clinical characteristics of the two diseases in order to improve the knowledge and diagnosis and treatment level of the clinicians on JE and other viral encephalitis.Method:The epidemiological and clinical data of children with JE(35 cases)and children with the other viral encephalitis(38 cases)admitted to the Affiliated Hospital of North Sichuan Medical College from June 2016 to September 2017 were selected and analyzed.Result:The cases of JE and other viral encephalitis were mainly concentrated in children under 6 years old.The onset of JE is from July to August,and 88.57%of children were from rural areas.Other viral encephalitis occured throughout the year,there were more cases in May,June and December,and there was no significant difference in incidence in rural areas and cities.The total number of leukocytes and neutrophile granulocyte in JE group were more significant higher than those in other viral encephalitis group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in hemoglobin levels and AST,LDH,creatinine levels between the two groups(P>0.05).The number of cerebrospinal fluid cells and protein levels in JE group were higher than those in other viral encephalitis group,and the differences were statistically significant(P<0.05).The cure rate of children with JE was 40.00%,and the invalidity/death rate was 14.29%,and there were different degrees of dysfunction in the children at discharge.The cure rate of other viral encephalitis children was 71.05%,the invalidity/death rate was 0,and only a small number of children had mild dysfunction when discharged.Conclusion:JE and the other viral encephalitis are different in terms of pathogen,geographical distribution,time of onset,transmission,prevention,severity and prognosis.Clinical manifestations are not specific.Clear diagn

关 键 词：流行性乙型脑炎 病毒性脑炎 临床分析 

分 类 号：R725.1[医药卫生—儿科]