不同强度低频重复经颅磁刺激治疗慢性耳鸣疗效研究  

The effect of different intensity and low frequency repetition transcranial magnetic stimulation on chronic tinnitus

作　　者：王延辉 薛瑞 袁杰 刘珂 Wang Yanhui;Xue Rui;Yuan Jei(Department of ENT,Xi’an No.3 Hospital(Xi’an 710018))

机构地区：[1]西安市第三医院耳鼻咽喉头颈外科,西安710018 [2]西安市中心医院耳鼻咽喉头颈外科,西安710003

出　　处：《陕西医学杂志》2018年第8期1026-1028,共3页Shaanxi Medical Journal

基　　金：西安市科技计划项目[2017116SF/YX010(9)]

摘　　要：目的:研究不同强度剂量低频(1Hz)重复经颅磁刺激(rTMS)对慢性耳鸣相关症状的治疗疗效。方法:58例慢性耳鸣患者随机分为低强度组和高强度组,低强度组治疗每天1次,高强度组每天2次,均每次20min,共10d。治疗前及治疗结束2周、4周应用耳鸣残疾度量表(THI)、主观视觉耳鸣标尺(VAS),计算各自得分及进行主观疗效评估。结果:本研究中58例慢性耳鸣患者经rTMS治疗2周后可以有效减轻耳鸣的响度、频率等,总体有效率为82.75%,高强度组耳鸣抑制效果更久、治疗的改善评分更显著。由于rTMS的生物学累积效应,治疗后4周所获得耳鸣抑制效果最佳,尤其对于改善耳鸣的响度和患者焦虑评分。结论:rTMS作为一种无创性神经调控治疗技术用于慢性耳鸣的治疗,患者均获得一定程度的主观症状改善,高强度的低频重复经颅磁刺激效果更明显。Objective:Study the effect of low frequency(1Hz)rTMS on the treatment of chronic tinnitus.Methods:58 patients with chronic tinnitus were randomly divided into high density group and low density group.The HD group received rTMS over contralesional motor cortex twice a day,while the LD group received rTMS once aday,20 minutes a time for 10 days.They were underwent a audiological protocol and interviewed with THI(tinnitus handicap inventory),and VAS.Data were analysed.Results:In this study,58 patients with chronic tinnitus were significantly reduced after 2 weeks of rTMS treatment,and the overall effective rate was 82.75%,and the effect of tinnitus suppression in the high-intensity group was longer and the improvement of treatment was more significant.Conclusion:rTMS as a noninvasive neural control technology for the treatment of chronic tinnitus treatment,all patients obtained a certain degree of subjective symptoms improved,high intensity of low-frequency repetitive transcranial magnetic stimulation effect is more obvious.

关 键 词：耳鸣/治疗 物理刺激/方法 疗效比较研究 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]