神经反馈治疗对注意力缺陷多动障碍儿童脑电相干性的影响  

Effects on EEG Coherence of ADHD Children by Neurofeedback Intervention

作　　者：王学韬 姚燕滨 郑旭媛[1] 岳伟[3] 王索刚[1] WANG Xue-tao;YAO Yan-bin;ZHENG Xu-yuan;YUE Wei;WANG Suo-gang(School of Biomedical Engineering and Technology,Tianjin Medical University,Tianjin 300070,China;Tianjin Women and Children Healthcare Center,Tianjin 300074,China;Tianjin Huanhu Hospital,Tianjin 300350,China)

机构地区：[1]天津医科大学生物医学工程与及技术学院,天津300070 [2]天津市妇女儿童保健中心,天津300074 [3]天津市环湖医院,天津300350

出　　处：《科学技术与工程》2018年第19期183-187,共5页Science Technology and Engineering

基　　金：国家自然科学基金(61175118;61471266);国家教育部留学回国人员科研启动基金(20111568);天津市自然科学基金(12JCYBJC19500)资助

摘　　要：比较Theta/beta神经反馈治疗前后脑电相干性的变化,从而证明神经反馈对注意力缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童脑电存在积极正向影响。通过采集16例ADHD患者神经反馈前后清醒闭眼脑电和16例正常儿童清醒闭眼脑电数据。研究了6个频段半球间和半球内脑电相干性。结果表明,神经反馈训练后ADHD儿童中短距离半球内theta频段相干性显著降低,长距离半球内theta和alpha频段相干性显著增加。在额区和颞区半球间alpha频段相干性显著增加并且theta频段相干性显著降低,在中央区-顶区-枕区半球间delta和theta频段相干性显著降低。可见,theta/beta神经反馈能影响ADHD儿童异常脑电活动,从而改善ADHD症状。神经反馈干预训练对脑电相干性有积极的影响,脑电相干性参数能够为评价神经反馈的作用提供一种客观的技术方法。EEG coherence difference during the theta/beta neurofeedback intervention was investigated while evaluate EEG coherence between pre-and post-neurofeedback training to prove the effectiveness of neurofeedback.16 ADHD children and 16 healthy controls were recruited.EEG coherence was calculated for intrahemispheric and interhemispheric electrode pairs for six frequency bands.The results show that,after neurofeedback training,ADHD participants have decreased short-medium intrahemispheric coherence in the theta and increased long distance intrahemispheric coherence in theta and alpha.Frontal and temporal interhemispheric coherences have increased in the alpha and reduced in theta,and central-parietal-occipital coherences have reduced in delta and theta.It is concluded that theta/beta neurofeedback protocol is able to alter brain activity so as to improve ADHD symptom.This intervention can have a positive influence upon EEG coherence.EEG coherence changes can provide objective and crucial evidence to evaluate the neurofeedback efficacy.

关 键 词：注意力缺陷/多动障碍 theta/beta 神经反馈 相干性 

分 类 号：R318[医药卫生—生物医学工程]