高脂血症通过系膜细胞-足细胞轴加重IgA肾病肾小管间质病变  

Hyperlipidemia may aggravate the renal tubulointerstitial lesionsin in IgA nephropathy by mesangial cells and podocyte axis

作　　者：高原[1] 杨林[1] 王建荣[1] 杨万霞[1] 傅淑霞[1] 张丽萍[1] GAO Yuan;YANG Lin;WANG Jianrong;YANG Wanxia;FU Shuxia;ZHANG Liping(Division of Nephrology,Hebei University Second Hospital,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院肾内科,石家庄050000

出　　处：《实用医学杂志》2018年第14期2385-2388,共4页The Journal of Practical Medicine

摘　　要：目的探讨高脂血症在IgA肾病肾小管间质损害中的意义。方法 59例IgA肾病患者按照牛津分型肾小管间质损伤程度进行分组,采用免疫组化法检测各组肾组织足细胞表面特异性标记物WT1及肾组织TNF-α、IL-6的表达变化。结果 IgA肾病患者三酰甘油与肾组织WT1表达呈显著负相关(r=-0.658,P<0.01);与肾小管间质TNF-α、IL-6表达及系膜增生程度、尿β2微球蛋白呈正相关(r=0.672,P<0.01,r=0.713,P<0.01,r=0.519,P<0.05 r=0.543,P<0.05);且与肾小管间质损害程度分级呈正相关(r=0.77,P<0.01)。结论 Ig AN脂代谢紊乱可能通过系膜细胞-足细胞轴加重IgA肾病肾小管间质病变。Objective To investigate the possible effect of hyperlipidemia on tubulointerstitial lesion in IgA nephropathy.Methods Fifty-nine patients diagnosed as primary IgA nephropathy by renal histology were in-volved.The patients were classified by the degree of tubulointerstitial lesion according to Oxford pathological type.The expression of WT1,TNF-α,IL-6 in renal tissue were detected by immunohistochemistry.Results There was a strong negative correlation of triglyceride(TG)in IgA nephropathy with the expression of WT1(r=-0.658,P<0.01);It associated positive correlation with the expression of TNF-α,IL-6 in tubulointerstitial,mesangial proliferative degree,urinary beta 2 microglobulin(r=0.672,P<0.01;r=0.713,P<0.01;r=0.519,P<0.05;r=0.543,P<0.05);And it also associated positive correlation with the degree of tubulointerstitial lesion(r=0.77 P<0.01).Conclusion In IgA nephropathy,hyperlipidemia may aggravate the renal tubulointerstitial lesionsin by mesangial cells and podocyte axis.

关 键 词：IGA肾病 高脂血症 系膜细胞-足细胞轴 肾小管间质损伤 

分 类 号：R589.2[医药卫生—内分泌] R692.31[医药卫生—内科学]