血清IL-17A水平在多囊卵巢综合征患者中的临床意义  

Role of serum IL-17A level in patients with polycystic ovary syndrome

作　　者：王晶[1] 陈丽[1] 刘春华[1] 李丽春[2] WANG Jing;CHEN Li;LIU Chunhua;LI Lichun(Department of Obstetrics,Maternal and Child Health Care Hospital of Baoji,Baoji 721000,Shaanxi,China;Department of Obstetrics,Yanan University Affiliated Hospital,Yanan 716000,Shaanxi,China)

机构地区：[1]宝鸡市妇幼保健院产科,陕西宝鸡721000 [2]延安大学附属医院产科一病区,陕西延安716000

出　　处：《检验医学》2018年第7期601-603,共3页Laboratory Medicine

基　　金：宝鸡市2013年科学技术研究发展计划项目(13SF4_2)

摘　　要：目的探讨血清白细胞介素(IL)-17A水平在多囊卵巢综合征(PCOS)患者中的临床意义。方法选取45例PCOS患者(PCOS组)、45名体检健康女性(正常对照组)及38例妇科其他原因导致不育的患者(疾病对照组)。检测所有研究对象血清硫酸脱氢表雄酮(DHEAS)、总睾酮(TT)水平。采用酶联免疫吸附试验(ELISA)检测血清IL-17A、IL-6和转化生长因子β_1(TGF-β_1)水平。结果 PCOS组血清TT、DHEAS、IL-17A、IL-6和TGF-β_1水平明显高于正常对照组和疾病对照组(P<0.05);TT与IL-17A、IL-6和TGF-β_1均呈明显正相关(r=0.632,P<0.01;r=0.650,P<0.05;r=0.708,P<0.05)。PCOS患者治疗后血清IL-17A、IL-6和TGF-β_1水平均明显低于治疗前。结论 PCOS患者血清IL-17A水平显著升高,可作为反映PCOS疗效的潜在生物标志物。Objective To investigate the role of serum interleukin(IL)-17A level in patients with polycystic ovary syndrome(PCOS).Methods A total of 45 PCOS patients were enrolled,45 healthy women were enrolled as healthy control group,and 38 non-PCOS patients were enrolled as disease control group.Serum levels of dehydroepiandrosterone sulphate(DHEAS)and total testosterone(TT)were determined.The levels of serum IL-17A,IL-6 and transforming growth factor beta1(TGF-β1)were determined by enzyme-linked immunosorbent assay(ELISA).Results Serum TT,DHEAS,IL-17A,IL-6 and TGF-β1 levels were higher in PCOS group than those in healthy and disease control groups(P<0.05).Serum level of TT was positively related to IL-17A,IL-6 and TGF-β1(r=0.632,P<0.01;r=0.650,P<0.05;r=0.708,P<0.05).After treatment,serum levels of IL-17A,IL-6 and TGF-β1 in PCOS group were lower than those before treatment.Conclusions PCOS patients have increased serum IL-17A level,and serum IL-17A could be a biomarker for PCOS.

关 键 词：白细胞介素17A 多囊卵巢综合征 临床意义 

分 类 号：R446.62[医药卫生—诊断学]