基于Mn掺杂ZnS量子点的室温磷光检测吡柔比星  

Detection of Pirarubicin by Room Temperature Phosphorescence Method Based on Mn Doped ZnS Quantum Dots

作　　者：王晶晶[1] 许强[1] 闫桂琴[1] WANG Jing-jing;XU Qiang;YAN Gui-qin(College of Life Science,Shanxi Normal University,Shanxi Linfen 041000,China)

机构地区：[1]山西师范大学生命科学学院,山西临汾041000

出　　处：《广州化工》2018年第13期66-69,共4页GuangZhou Chemical Industry

基　　金：国家自然科学基金项目(31272258);国家教育部博士点联合基金项目(20111404110002);山西省重点化学优势学科建设项目(912019)

摘　　要：以3-巯基丙酸(MPA)为稳定剂采用水相合成法合成Mn掺杂Zn S量子点,基于MPA包裹的Mn掺杂Zn S量子点的室温磷光性质,建立了一种高效、灵敏的检测蒽醌类抗癌药物吡柔比星(Pirarubicin,THP)的新方法。在p H=7.4的磷酸盐缓冲溶液中,THP通过光诱导电子转移可以猝灭Mn掺杂Zn S QDs在波长590 nm处的磷光,且在一定范围内THP的浓度与磷光猝灭强度呈正比例关系,线性范围为0.3~16.2μg/m L,相关系数为0.992,方法检出限为0.072μg/m L。Using 3-mercaptopropionic acid(MPA)as the stabilizer,MPA-capped Mn-doped ZnS QDs were synthesized via water phase method.Based on the room temperature phosphorescence properties of quantum dots,a highperformance and high-sensitivity method was established for detection of anthraquinone anticancer drug pirarubicin(THP).In the phosphate buffer of pH=7.4,the room temperature phosphorescence(RTP)at 590 nm of Mn-doped quantum dots were quenched through photoinduced electron transfer principle,the concentration of THP had a good linear relationship with the phosphorescence quenching intensity,linear scope of 0.3~16.2μg/mL,and the detection limit and standard addition recovery of 0.072μg/mL(correlation coefficient R=0.992).

关 键 词：Mn掺杂ZnS量子点 吡柔比星 室温磷光检测 

分 类 号：O657.3[理学—分析化学]