冠状动脉慢血流现象的影响因素及临床研究  

Influential factors and clinical study of coronary artery slow blood flow

作　　者：陈玄祖[1] Chen Xuanzu(Department of Cardiology,Beijing Anzhen Hospital,Capital University of Medical Sciences,Beijing100029,China)

机构地区：[1]首都医科大学附属北京安贞医院,北京100029

出　　处：《中国循证心血管医学杂志》2018年第6期743-745,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨影响冠状动脉慢血流现象的形成因素,观察前列地尔治疗冠脉慢血流现象(CSFP)的疗效和相关临床研究。方法选取首都医科大学附属北京安贞医院心内科于2017年1月~12月收治的冠状动脉慢血流患者142例,随机分为观察组(n=72)和对照组(n=70),对照组常规应用硝酸酯类及阿司匹林治疗,观察组在对照组的治疗基础上加用前列地尔注射液治疗。观察所有病例的临床症状恢复、冠脉血流变化及高敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)改变等情况。结果观察组中其饮酒、吸烟史高于对照组,观察组血小板平均容积(MPV)高于对照组(P<0.01)。观察组中患者胸痛症状改善明显高于对照组;观察组校正的TIMI帧数(CTFC)与对照组比较,下降更为明显,P<0.05,其差异具有统计学意义。结论大量饮酒、吸烟、MPV增高等均可能是冠状动脉慢血流发生的因素,临床应用前列地尔治疗CSFP有明显效果,值得推广。Objective To investigate the factors influencing the slow flow of coronary arteries,and to observe the efficacy and related clinical studies of alprostadil in the treatment of coronary slow flow(CSFP).Methods 142 patients with coronary artery slow blood flow admitted to the Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University from January to December 2017 were randomly divided into observation group(n=72)and control group(n=70).The group was routinely treated with nitrates and aspirin,and the observation group was treated with alprostadil in the treatment of the control group.Clinical symptoms recovery,coronary blood flow changes,and high-sensitivity C-reactive protein(hs-CRP)and homocysteine(Hcy)changes were observed in all cases.Results The alcohol consumption and smoking history in the observation group were higher than those in the control group.The mean platelet volume(MPV)of the observation group was higher than that of the control group(P<0.01).The improvement of chest pain symptoms in the observation group was significantly higher than that in the control group;the corrected TIMI frame number(CTFC)in the observation group was more significant than that in the control group,P<0.05,and the difference was statistically significant.Conclusion A large number of alcohol consumption,smoking,and increased MPV may be the factors of slow coronary flow.The clinical application of alprostadil in the treatment of CSFP has obvious effects and is worthy of promotion.

关 键 词：冠脉造影 慢血流现象 前列地尔 

分 类 号：R543.3[医药卫生—心血管疾病]