滋肾育胎丸对体外受精-胚胎移植中生化妊娠患者的疗效观察  

Clinical observation on treating biochemical pregnancy with Zishen Yutai Wan

作　　者：姚建凤 黄燕芳[2] 王育梅 陈小莉 黄荣富[3] 

机构地区：[1]泉州市妇幼保健院,福建泉州362000 [2]福建医科大学附属第一医院体检中心,福建福州350004 [3]福建医科大学附属第二医院,福建泉州362000

出　　处：《中医临床研究》2018年第15期102-105,共4页Clinical Journal Of Chinese Medicine

基　　金：泉州市科技局2016年度科技计划项目(2016Z38)资助;泉州市科技项目B类课题([2004]0010)资助

摘　　要：目的:观察中药滋肾育胎丸在体外受精-胚胎移植(IVF-ET)中对生化妊娠不孕患者的临床意义。方法:收集IVFET中符合纳入标准的不孕患者72例,随机分为对照组和治疗组各36例,所有患者均采用Gn RHa黄体中期降调节卵巢刺激方案,治疗组对照组的基础上,促排卵前一周期月经第三天开始服用滋肾育胎丸。结果:与对照组相比,治疗组HCG日子宫内膜厚度、2PN受精率、D3优胚率、囊胚形成率、可利用囊胚率、临床妊娠率和胚胎种植率明显提高,相反治疗组生化妊娠率明显下降,均具统计学差异(P<0.05)。结论:IVF-ET中使用滋肾育胎丸有助于改善卵子及胚胎质量,促进胚胎着床成功,降低生化妊娠风险,进而提高临床妊娠率。Objective:To observe the clinical efficacy of Zishen Yutai Wan(滋肾育胎丸)in vitro fertilization-embryo transfer(IVF-ET)on infertile patients with biochemical pregnancy.Methods:72 infertile patients with biochemical pregnancy were selected in this study and were randomly divided into control group and treatment group,36 cases in each group.For all the patients,the gonadotropinreleasing hormone agonist(GnRH-a)protocol was operated for controlled ovarian hyperstimulation(COH),and GnRH-a was started in the mid-luteal phase of previous menstrual cycle for pituitary down-regulation.Based on the control group,the treatment group was given Zishen Yutai Wan on menstruation day 3 a cycle before ovulation induction.Results:The endometrium thickness on HCG injection day,2PN fertilization rate,D3 good quality embryo rate,blastocyst formation rate,usable blastocyst rate,clinical pregnancy rate and embryo implantation rate in the treatment group were significantly higher than those in the control group,and the biochemical pregnancy rate decreased significantly(P<0.05).Conclusion:The use of Zishen Yutai Wan in IVF-ET treatment can improve the quality of oocytes and embryos,promote the embryo implantation,reduce the risk of biochemical pregnancy,and finally increase the clinical pregnancy rate.

关 键 词：滋肾育胎丸 生化妊娠 体外受精-胚胎移植 

分 类 号：R289.6[医药卫生—方剂学]