自拟黄疸汤结合常规保肝疗法治疗小儿急性黄疸型肝炎的疗效分析  

Effect of Self-Made Huangdan Decoction Combined with Routine Hepatoprotective Therapy on Acute Icteric Hepatitis in Children

作　　者：安贺娟[1] 王建玲[2] 杨帆[1] 王艳[2] 和萍 李艳君[4] AN Hejuan;WANG Jianling;YANG Fan;WANG Yan;HE Ping;LI Yanjun(Department of Tuberculosis,Shijiazhuang,Hebei 050041,China;Department of Pediatrics,Shijiazhuang,Hebei 050041,China;Department of Traditional Chinese Medicine,Shijiazhuang,Hebei 050041,China;Department of Respiration,Shijiazhuang,Hebei 050041,China)

机构地区：[1]河北省胸科医院结核科,河北石家庄050041 [2]河北省胸科医院儿科,河北石家庄050041 [3]河北省胸科医院中医科,河北石家庄050041 [4]河北省胸科医院呼吸科,河北石家庄050041

出　　处：《湖南中医药大学学报》2018年第7期811-813,共3页Journal of Hunan University of Chinese Medicine

基　　金：河北省卫生和计划生育委员会科研课题(2016WS0219)

摘　　要：目的探讨自拟黄疸汤结合常规保肝疗法治疗小儿急性黄疸型肝炎的临床疗效。方法选取2016年10月至2017年10月本院收治的急性黄疸型肝炎患儿98例,随机分为观察组和对照组(每组49例)。对照组采取常规保肝疗法(门冬氨酸钾镁静脉滴注,肌酐、维生素C及能量合剂支持治疗),观察组在对照组的基础上,加用自拟黄疸汤并随症加减。观察两组患儿治疗前后肝功能检查相关指标的变化情况,包括丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL);观察治疗后两组患儿的临床疗效和毒副反应。结果治疗后两组患儿的ALT、AST及TBIL含量均较治疗前明显降低(P<0.01);且治疗后观察组ALT、AST和TBIL显著低于对照组,差异有统计学意义(P<0.05或P<0.01)。观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组患儿在治疗过程中均未发生任何明显的毒副反应。结论自拟黄疸汤结合常规保肝疗法治疗小儿急性黄疸型肝炎疗效显著,安全可靠,值得临床推广。Objective To explore the clinical efficacy of self-made Huangdan decoction combined with routine hepatoprotective therapy in the treatment of acute jaundice hepatitis in children.Methods 98 children with acute icteric hepatitis admitted to our hospital from October 2016 to October 2017 were randomly divided into the observation group and the control group(49 cases in each group).The control group was treated with conventional liver preservation(potassium aspartate magnesium intravenous drip,creatinine,vitamin C and energy mixture support).On the basis of the control group,the observation group was added with the self-made Huangdan decoction and its dosage changed with the disease.The changes of the related indexes including alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)of liver function examination before and after treatment were observed in the two groups.clinical efficacy and side effects of the two groups were observed after treatment.Results After treatment,the contents of ALT,AST and TBIL in the two groups were significantly lower than those before treatment(P<0.01),and the ALT,AST and TBIL in the observation group were significantly lower than those in the control group.The difference was statistically significant(P<0.05 or P<0.01).The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).No obvious side effects were observed in the two groups during the treatment.Conclusion Self-made Huangdan decoction combined with routine liver protection therapy is effective,safe and reliable for children with acute icteric hepatitis,and is worthy of clinical promotion.

关 键 词：小儿急性黄疸型肝炎 自拟黄疸汤 常规保肝疗法 丙氨酸氨基转移酶 天门冬氨酸氨基转移酶 总胆红素 

分 类 号：R256.4[医药卫生—中医内科学]