非洲狮肝内胆管癌的病理形态学研究  

Pathological Changes of Intrahepatic Holangiocacinoma in an African Lion

作　　者：邱波 刘青 仉伟[2] 英永 王凤乾 张海静 胡建廷 Qiu Bo;Liu Qing;Zhang Wei;Ying Yong;Wang Fengqian;Zhang Haijing;Hu Jianting(Shandong Pharmaceutical Academy,Jinan,250101,China;Jinan Zoo,Jinan,250031,China)

机构地区：[1]山东省药学科学院,济南250101 [2]济南动物园管理处,济南250031

出　　处：《野生动物学报》2018年第3期648-651,共4页CHINESE JOURNAL OF WILDLIFE

基　　金：山东抗体类和疫苗类生物药物临床前评价公共服务平台的完善与运行(2015CXPT00001)

摘　　要：肝内胆管癌(ICC)是指左右肝管汇合部以上的胆管上皮细胞起源的恶性肿瘤,也称胆管细胞癌或外周型胆管癌。目前人们已经建立了多种实验动物模型来研究肝内胆管癌并积累了相关的病例资料,但对于野生动物来说,肝内胆管癌的病例较为罕见,对其缺乏足够的了解。本研究将通过肉眼形态学及组织病理学观察的方法,对来自于济南某动物园的一例自发性非洲狮的肝内胆管癌进行初步的探讨。Intrahepatic cholangiocarcinoma(ICC)refers to malignant tumors of bile duct epithelial origin above the junction of the left and right hepatic duct,also called cholangiocarcinoma or peripheral cholangiocarcinoma.Many experimental animal models have been developed to study ICC and accumulate relevant case data.However,the cases of ICC are rare in wildlife and lack sufficient understanding.In this study,a case of spontaneous lioness ICC from a zoo was initially explored by gross morphology and histopathological observation.

关 键 词：非洲狮 肝脏 肝内胆管癌 病理形态学 

分 类 号：S856.4[农业科学—临床兽医学]