美托洛尔联合普罗帕酮对儿童心律失常心电图及心率变异指数的影响研究  

Effects of Metoprolol combined with Propafenone on electrocardiogram and heart rate variability index in children with arrhythmia

作　　者：刘琦 LIU Qi(Department of Cardiology,Beijing Children's Hospital,Capital Medical University,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院心内科,北京100045

出　　处：《中国医学前沿杂志（电子版）》2018年第5期103-106,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨美托洛尔联合普罗帕酮对儿童心律失常心电图及心率变异指数的影响。方法将2014年4月至2017年4月于本院儿科住院的90例心律失常患儿按照随机数表法分为对照组与观察组,每组各45例。嘱两组患儿卧床休息,积极治疗原发性疾病,包括抗病毒、抗感染、纠正水电解质紊乱、解热、吸氧及保护心功能等,并注意定期复查心电图。对照组患儿在上述基础治疗基础上采用普罗帕酮治疗,观察组患儿在对照组治疗基础上采用美托洛尔治疗。比较两组患儿的临床疗效、治疗前后心电图及心率变异指数变化情况。结果观察组患儿治疗总有效率显著高于对照组(93.33%∶73.33%,P=0.032);治疗后两组患儿房性期前收缩、短阵房性心动过速、室性期前收缩以及短阵室性心动过速频次均显著小于治疗前(P<0.05),且观察组患儿上述指标均显著小于对照组(P<0.05)。治疗后两组患儿24小时所有窦性心搏RR间期的标准差、24小时每隔5分钟窦性心搏RR间期均值的标准差、24小时每隔5分钟所有窦性心搏RR间期标准差的均值、24小时相邻窦性心搏RR间期差值>50毫秒百分率均显著高于治疗前(P<0.05),且观察组患儿上述指标均显著高于对照组(P<0.05)。结论美托洛尔联合普罗帕酮可显著改善心律失常症状、降低心律失常的发作频率,临床疗效显著优于单用普罗帕酮,值得推广应用。Objective To investigate the effect of Metoprolol combined with Propafenone on electrocardiogram and heart rate variability index in children with arrhythmia.Method 90 children with arrhythmia admitted to our hospital from April 2014 to April 2017 were divided into control group and observation group according to the random number table method,45 cases in each group.First of all,asked children of the two groups in bed rest,treated the primary diseases actively,including the use of anti-virus,anti-infection,corrected the disorders of water and electrolyte,antipyretic,oxygen inhalation and protect the heart function and other treatment,and periodic review the electrocardiogram(ECG).The control group children were treated with Propafenone on the basis of the basic treatment.The observation group children were treated with Metoprolol on the basis of control group.Clinical efficacy,ECG and heart rate variability index before and after treatment were compared between the two groups.Result The total effective rate of the observation group was significantly higher than that of the control group(93.33%∶73.33%,P<0.05).After treatment,the frequency of atrial premature contraction,short atrial tachycardia,ventricular tachycardia,and short ventricular tachycardia in the two groups were significantly lower than those before treatment(P<0.05),and the above indexes in the children of the observation group were significantly smaller than those in the control group(P<0.05).The standard deviation of the RR interval of all sinus beats at 24 hours after treatment,the standard deviation of the mean of the sinus heart RR interval of 24 hours every 5 minutes,the mean value of the standard deviation of the RR interval of the sinus heart every 5 minutes every 5 minutes,and the difference of the RR interval of the adjacent sinus heart beat between the 24 hours and the 50 milliseconds of the 24 hours were significantly higher than those before the treatment(P<0.05).And the above indexes in the observation group were significantly higher t

关 键 词：儿童 心律失常 美托洛尔 普罗帕酮 心电图 心率变异指数 

分 类 号：R725.4[医药卫生—儿科]