MTHFR C677T基因多态性与儿童法洛四联症相关性的meta分析  

Meta-analysis of the correlation between MTHFR C677T gene polymorphism and tetralogy of Fallot in children

作　　者：黄娟娟[1] 张利平[1] 李华[1] 岳红云[1] 张娟[1] HUANG Juanjuan;ZHANG Liping;LI Hua;YUE Hongyun;ZHANG Juan(Department of Gynecology,Yan’an University Affiliated Hospital,Yanan 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院产科,陕西延安716000

出　　处：《临床儿科杂志》2018年第7期549-552,562,共5页Journal of Clinical Pediatrics

摘　　要：目的探讨5,10-亚甲基四氢叶酸还原酶(MTHFR)基因多态性(C677T)与儿童法洛四联症的相关性。方法检索Pub Med、中国知网、万方和维普数据库,收集2017年7月以前发表的MTHFR基因多态性(C677T)与儿童法洛四联症病例的对照研究文献,根据纳入和排除标准,剔除不符合要求的文献,行Hardy-Weinberg遗传平衡检验后进行meta分析,并采用序贯试验分析(TSA)方法对结果进行检验。结果共有7篇文献纳入分析,包括1 222例法洛四联症患儿和1 443例对照儿童。Meta分析结果显示,MTHFR基因多态性(C 677 T)位点等位基因模型(T对C)合并后的总OR值为1.63,95%CI:1.41～1.88;显性基因模型(TT+TC对CC)合并后的总OR值为1.67,95%CI:1.34～2.10;隐性基因模型(TT对TC+CC)合并后的总OR值为2.08,95%CI:1.64～2.63;共显性杂合子基因模型(TC对CC)合并后的总OR值为1.36,95%CI:1.07～1.74;共显性纯合子基因模型(TT对CC)合并后的总OR值为2.56,95%CI:1.92～3.41。结论 MTHFRC 677 T基因多态性位点可增加法洛四联症风险。Objective To explore the correlation between 5,10-methylenetetrahydrofolate reductase(MTHFR)gene polymorphism(C677T)and tetralogy of Fallot in children.Method PubMed,China National Knowledge Infrastructure,Wanfang and VIP databases were searched.A comparative study of MTHFR gene polymorphism(C677T)and tetralogy of Fallot in children published before July 2017 were collected.According to the inclusion and exclusion criteria,the documents which did not meet the requirements were excluded.After having Hardy-Weinberg genetic balance test,meta-analysis was performed and sequential test analysis(TSA)was used to test the results.Results A total of 7 articles were included,including 1222 cases of tetralogy of Fallot and 1443 of controls.The results of meta analysis showed that the total OR value of the MTHFR gene polymorphism(C677T)allele model(T to C)was 1.63 with 95%CI of 1.41~1.88.The total OR value of the dominant gene model(TT+TC to CC)was 1.67 with 95%CI of 1.34~2.10.The total OR value of the recessive gene model(TT to TC+CC)was 2.08 with 95%CI of 1.64~2.63.The total OR value of the co-dominant heterozygote gene model(TC to CC)was 1.36 with 95%CI of 1.07~1.74.The total OR value of the co-dominant homozygote gene model(TT to CC)was 2.56 with 95%CI of 1.92~3.41.Conclusion The MTHFR C677T gene polymorphic loci can increase the risk of tetralogy of Fallot.

关 键 词：MTHFR基因 法洛四联症 基因多态性 META分析 试验序贯分析 

分 类 号：R725.4[医药卫生—儿科]