放置曼月乐环和口服避孕药治疗子宫腺肌病的疗效对比观察  

Comparison of levonogestrel-releasing intrauterine system and oral contraceptive for treatment of adenomyosis

作　　者：黄立冬[1] 吴玉英[1] 陈昌益[1] 黄伟容[1] 阳霞 韦利英[1] HUANG Li-dong;WU Yu-ying;CHEN Chang-yi(Department of Gynecology,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院妇科,南宁530021

出　　处：《中国临床新医学》2018年第7期632-635,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西科技攻关计划项目(编号:桂科攻1298003-8-5)

摘　　要：目的对比放置曼月乐环和低剂量复方口服避孕药(COC)治疗子宫腺肌病患者疼痛和月经过多的临床效果。方法 62例主诉疼痛和月经过多的子宫腺肌病患者随机分为曼月乐环组和COC组。采用视觉模拟评分法(visual analogue scale,VAS)评估疼痛程度,用月经日记评估月经血量和超声检查估计子宫体积的变化。对比两组患者治疗6个月前后的疼痛程度、月经量和子宫体积的变化情况。结果两种方法治疗6个月后,疼痛均明显减轻,而且曼月乐环组与COC组相比效果更为明显(P<0.01);两种治疗方法均显著减少子宫出血量,子宫体积明显缩小,且曼月乐环组比COC组显著(P<0.01)。结论曼月乐环和COC用于子宫腺肌病的治疗,均能减轻相关疼痛及减少月经出血量,放置曼月乐环比口服COC疗效更好。Objective To compare the efficacy of a levonorgestrel-releasing intrauterine system(LNG-IUS)and a low-dose combined oral contraceptive(COC)in reducing adenomyosis-related pain and bleeding.Methods Sixty-two patients with adenomyosis complained of pain and bleeding that were associated with adenomyosis were randomly divided into LNG-IUS group and COC group.The outcomes included the improvement of pain release using a visual analogue scale,menstrual blood loss using a menstrual diary and estimated uterine volume by ultrasound were compared before and 6 months after treatment.Results The adenomyosis-related pain was relieved obviously and the adenomyosis-related bleeding was remarkably reduced and the sizes of uterine were decreased obviously in both of the two groups 6 months after treatment(P<0.01),however the improvements of the pain release and bleeding in LNG-IUS group were better than those in COC group(P<0.01).Conclusion Both LNG-IUS and COC can relieve the adenomyosis-related pain and reduce the menstrual bleeding.However,LNG-IUS is more effective than COC for treatment of adenomyosis.

关 键 词：子宫腺肌病 复方口服避孕药 曼月乐环 痛经 

分 类 号：R71[医药卫生—妇产科学]