广西壮族自治区先天性甲状腺功能减低症筛查TSH切值在GSP分析仪上的设定  

Setting of the TSH-cutoff value in screening for congenital hypothyroidism with GSP in Guangxi area

作　　者：林彩娟[1] 玉晋武[1] 耿国兴[1] 黄小桃 何春雨[1] LIN Caijuan;YU Jinwu;GENG Guoxing;UANG Xiaotao;HE Chunyu(Genetic Metabolism Center,the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi Zhuang Autonomous Region 530003,China)

机构地区：[1]广西壮族自治区妇幼保健院遗传代谢中心,南宁530003

出　　处：《重庆医学》2018年第20期2666-2667,2672,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81260126);广西壮族自治区自然科学基金资助项目(2012GXNSFAA053174);广西壮族自治区卫生厅重点课题(重2012025)

摘　　要：目的建立广西壮族自治区地区新生儿先天性甲状腺功能减低症促甲状腺激素(TSH)筛查在全自动免疫荧光分析仪(GSP)上的切值。方法对已用1235全自动时间分辨荧光免疫分析仪检测的2 044例干血片进行GSP上的TSH检测,将数据进行分析,使用百分位数法和应试者操作特征曲线(ROC)研究在GSP上先天性甲状腺功能减低症筛查的TSH最佳切值点。结果百分位数法99%可信限位为32.4μIU/mL;ROC曲线法临界值为8.22μIU/mL。结论参考ROC曲线法,切值定在8.0μIU/mL。Objective To establish the screening values for thyroid-stimulating hormone(TSH)screening on the automatic immunofluorescence analyzer(GSP)in newborns with congenital hypothyroidism in Guangxi.Methods Using 1235 automatic detection of time-resolved fluorescence immunoassay analyzer,2 044 cases of dried blood tablets were performed for TSH testing on GSP,the data was analyzed using the percentile method and the candidate operating characteristic curve(ROC)to study the optimal cut-off point for TSH screening for congenital hypothyroidism.Results The 99%confidence limit for the percentile method was 32.4μIU/mL;the critical value for the ROC curve method was 8.22μIU/mL.Conclusion With reference to ROC curve method,the tangent value is 8.0μIU/mL.

关 键 词：广西壮族自治区 先天性甲状腺功能减低症 促甲状腺激素切值 全自动免疫荧光分析仪 

分 类 号：R581.2[医药卫生—内分泌]