丹参多酚酸盐联合甲钴胺对糖尿病周围神经病变患者血清IGF-1 IGFBP-1 BDNF MBP及周围神经传导速度的影响  

Effects of Salvianolate Combined with Mecobalamin on Serum IGF-1 IGFBP-1 BDNF MBP and Peripheral Nerve Conduction Velocity in Patients with Diabetic Peripheral Neuropathy

作　　者：帕力达.克立木 白婷迪娜[1] 冒文娟[1] KE Li Mu-Palida;BAI Tingdina;MAO Wenjuan(The Xinjiang Uygur Autonomous Region People's Hospital,Xinjiang Urumqi 830000,China)

机构地区：[1]新疆维吾尔自治区人民医院神经内科,新疆乌鲁木齐830000

出　　处：《河北医学》2018年第7期1104-1108,共5页Hebei Medicine

基　　金：新疆自治区自然科学基金;(编号:2014211A066)

摘　　要：目的:探讨丹参多酚酸盐联合甲钴胺对糖尿病周围神经病变患者血清胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白1(IGFBP-1)、人脑源性神经营养因子(BDNF)、人髓磷脂碱性蛋白(MBP)及周围神经传导速度的影响。方法:选择2015年9月至2017年10月在我院接受治疗的136例糖尿病周围神经病变患者进行研究,采用随机数字表法将其分为观察组(69例)和对照组(67例),对照组患者给予甲钴胺进行治疗,而观察组则在对照组治疗方案的基础上增加丹参多酚酸盐进行治疗。分别记录两组患者治疗前、治疗后10d、治疗后20d的IGF-1、IGFBP-1、BDNF、MBP、MCV、SCV、空腹血糖、餐后2h血糖水平值,以及治疗后的生活质量情况,并比较两组变化情况,进而对临床疗效作出综合评价。结果:观察组患者的总有效率显著高于对照组[92.75%>76.12%](P<0.05);治疗后10d及治疗后20d,两组患者的IGF-1、BDNF、MCV、SCV水平较治疗前显著升高,且观察组高于对照组(P<0.05);两组患者的IGFBP-1、MBP、空腹血糖、餐后2h血糖水平以及生活质量评分较治疗前明显降低,且观察组低于对照组(P<0.05)。结论:丹参多酚酸盐联合甲钴胺治疗糖尿病周围神经病变患者的临床疗效显著,不仅能改善血清IGF-1、IGFBP-1、BDNF、MBP水平,而且能调节周围神经传导速度,提高生活质量。Objective:To study the effects of salvianolate combined with mecobalamin on serum insulin-like growth factor 1(IGF-1),insulin-like growth factor binding protein 1(IGFBP-1),human brain-derived neurotrophic factor(BDNF),Human myelin basic protein(MBP)and peripheral nerve conduction velocity.Methods:A total of 136 patients with diabetic peripheral neuropathy who were treated in our hospital from September 2015 to October 2017 were selected for study.They were randomized into observation group(69 cases)and control group(67 cases).The patients in the control group were treated with mecobalamin,while the observation group was treated with salvianolate in the control group.The IGF-1,IGFBP-1,BDNF,MBP,MCV,SCV,fasting blood glucose,and postprandial blood glucose levels were recorded before treatment,10 days after treatment,and 20 days after treatment,as well as the quality of life after treatment.And compare the two groups of changes,and then make a comprehensive evaluation of clinical efficacy.Results:The total effective rate in the observation group was significantly higher than that in the control group[92.75%>76.12%](P<0.05);at 10 days after treatment and 20 days after the treatment,the levels of IGF-1,BDNF,MCV,and SCV were higher in the two groups of patients.Significantly increased before treatment,and the observation group was higher than the control group(P<0.05);IGFBP-1,MBP,fasting blood glucose,2h postprandial blood glucose levels and quality of life scores were significantly lower in the two groups than before treatment,and the observation group Lower than the control group(P<0.05).Conclusion:Salviae miltiorrhizae polyphenols combined with mecobalamin treatment of diabetic peripheral neuropathy patients with significant clinical efficacy,not only can improve serum IGF-1,IGFBP-1,BDNF,MBP levels,but also regulate the peripheral nerve conduction velocity and improve quality of life.

关 键 词：丹参多酚酸盐 甲钴胺 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]