三维液体衰减反转恢复序列磁共振成像在梅尼埃病中的显影效果及成像时间窗的初步探讨  

Preliminary study on development effect and imaging time window of 3D fluid-attenuated inversionrecovery sequence of magnetic resonance imaging in Meniere's disease

作　　者：付佳[1] 区永康[2] 高志娟[1] 刘彤 汪欣[1] 杨燕珍[1] 祝晓芬[1] 许耀东[2] Fu Jia;Ou Yongkang;Gao Zhijuan;Liu Tong;Wang Xin;Yang Yanzhen;Zhu Xiaofen;Xu Yaodong(Huizhou First People's Hospital,Huizhou 516003,China;Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510000,China)

机构地区：[1]惠州市第一人民医院,516003 [2]中山大学孙逸仙纪念医院,广州510000

出　　处：《国际医药卫生导报》2018年第13期1910-1913,共4页International Medicine and Health Guidance News

基　　金：2015年广东省医学科学技术研究基金项目(A2015623);2015年惠州市科技计划项目(2015Y078)。

摘　　要：目的 通过研究梅尼埃病患者在钆喷酸葡胺(Gd-DTPA)咽鼓管给药后使用3D-FLAIR检测耳蜗、前庭显影效果,探讨3D-FLAIR检测耳梅尼埃病内耳增强的最佳时间窗。方法 选择惠州市第一人民医院12例梅尼埃疾病患者作为研究对象,在经咽鼓管注入Gd-DTPA后分别在4、12、24 h对受试者进行内耳3D-FLAIR MRI扫描。比较该序列下患侧耳蜗和前庭的信噪比以及显影情况。结果 鼓室注射7倍稀释的Gd-DTPA后24 h内前庭的信号强度持续增加,其信号峰值为24 h,而耳蜗的信号峰值为12 h,耳蜗信号均在24 h稍有降低,但差异无统计学意义(P>0.05)。结论 在3D-FLAIR检测中,注入对比剂Gd-DTPA 24 h后前庭部显影最佳,而耳蜗注药后12~24 h进行扫描均可。Objective To study the development effect of 3D fluid-attenuated inversion-recovery(3D-FLAIR)sequence in detecting cochlea and vestibule in patients with Meniere's disease after eustachian tube(ET)administration of gadopentetate dimeglumine(Gd-DTPA),and to explore the optimum time window of 3D-FLAIR for detecting the enhancement of inner ear in patients with Meniere's disease.Methods 12 patients with Meniere's disease in our hospital were included as study subject.The inner ear 3D-FLAIR imaging was performed at 4 h,12 h,and 24 h after ET injection of Gd-DTPA.Signal-noise ratio(SNR)and development effect of the affected cochlea and vestibule in 3D-FLAIR sequence were compared.Results The signal intensity of the vestibule increased continuously within 24 h after ET injection of 7 times-diluted Gd-DTPA,with the peak signal occurred at 24 h after Gd-DTPA injection;and the signal intensity of the cochlea decreased slightly within 24 h after Gd-DTPA injection,with the peak signal occurred at 12 h after Gd-DTPA injection,but without statistically significant difference(P>0.05).Conclusion In 3D-FLAIR examination,optimum development of vestibule was observed at 24 h after contrast medium Gd-DTPA injection,and cochlea scanning could be performed at 12-24 h after contrast medium Gd-DTPA injection.

关 键 词：三维液体衰减反转恢复序列 磁共振成像 梅尼埃病 

分 类 号：R445.2[医药卫生—影像医学与核医学]