法舒地尔注射液辅助手术治疗脑外伤对应激激素、炎症因子的影响及对ACTH、NE、Cor的观察  

Effect of Fasudil Injection on Stress Hormones and Inflammatory Factors in Patients with Traumatic Brain Injury and the Observation of ACTH, NE and Cor

作　　者：武宏杰[1] 李静[1] WU Hong-jie;LI Jing(Department of Neurosurgery,Kaiyuan hospital,First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)

机构地区：[1]河南科技大学第一附属医院开元院区神经外科,河南洛阳471000

出　　处：《药品评价》2018年第14期38-40,共3页Drug Evaluation

摘　　要：目的:分析讨论法舒地尔注射液辅助手术治疗脑外伤对应激激素、炎症因子的影响及对ACTH、NE、Cor的影响。方法:选取我院2014年1月—2018年1月收治的脑外伤患者60例,按照其入院号随机分为对照组和观察组,每组30例患者,对照组在术后给予常规治疗,观察组在术后以常规治疗为基础使用法舒地尔注射液治疗,经过治疗后,比较分析两组患者的治疗疗效、血清应激激素水平以及血清炎症因子水平。结果:在治疗后,观察组治疗疗效高于对照组,ACTH、NE、Cor水平均低于对照组,IL-1、IL-6、TNF-а水平也低于对照组,差异具有统计学意义,P<0.05。结论:法舒地尔注射液辅助手术治疗脑外伤的治疗效率较好,有很高的临床应用价值。Objective:To analyze and discuss the effect of fasudil injection on the stress hormones and inflammatory factors and their effects on ACTH,NE and Cor in the treatment of traumatic brain injury.Methods:60 cases of brain trauma in our hospital from January 2014 to January 2018 were selected and divided into the control group and the observation group randomly according to their admission number.Each group was treated with 30 patients.The control group was given routine treatment after the operation.The observation group was treated with the routine treatment on the basis of the routine treatment.After treatment,the therapeutic effects,serum levels of hormones and serum inflammatory factors in the two groups were compared.Results:After treatment,the therapeutic effect of the observation group was higher than that of the control group(P<0.05).The levels of ACTH,NE and Cor were lower than those of the control group(P<0.05).The levels of IL-1,IL-6 and TNF-were lower than those of the control group(P<0.05).Conclusion:Fasudil injection is effective in the treatment of traumatic brain injury,and has high clinical application value.

关 键 词：法舒地尔注射液 手术 辅助 脑外伤 应激激素 炎症因子 

分 类 号：R982[医药卫生—药品]