阿瑞匹坦在肺癌多疗程含顺铂化疗中止吐作用的临床研究  

Efficacy of Aprepitant in Prevention of Vomiting During Multiple Cycles of Cisplatin-based Chemotherapy in Lung Cancer

作　　者：别志欣[1] 张帅[2] 李旭[2] 张子瑾[2] 艾斌[2] 程刚[2] BIE Zhi-xin;ZHANG Shuai;LI Xu;ZHANG Zi-jin;AI Bin;CHENG Gang(Minimally Invasive Tumor Therapies Center,Beijing Hospital,National Center of Gerontology,Beijing 100730,China;Department of Medical Oncology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China)

机构地区：[1]北京医院国家老年医学中心肿瘤微创治疗中心,北京100730 [2]北京医院国家老年医学中心肿瘤内科,北京100730

出　　处：《中国药物警戒》2018年第6期329-332,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的研究阿瑞匹坦在肺癌多疗程含顺铂化疗中的止吐疗效及安全性。方法回顾性研究纳入完成4程或6程含顺铂化疗的95例肺癌患者。所有患者均接受阿瑞匹坦联合止吐治疗:阿瑞匹坦(125 mg,口服,D1;80 mg,口服,D2~D3)、昂丹司琼(8 mg,静脉注射,2次/d,D1~D3)和地塞米松(5 mg,静脉注射,1次/d,D1~D3)。分析各疗程化疗期间的呕吐完全缓解率、无恶心率及不良反应。结果 95例肺癌患者纳入研究,22例患者完成4程化疗,73例患者完成6程化疗。呕吐完全缓解率71.2%~78.9%,无恶心率61.1%~68.4%,连续6程化疗中阿瑞匹坦联合止吐疗效无显著降低。多因素分析显示肝转移是首疗程患者呕吐的危险因素。不良反应有1级或2级乏力、便秘、呃逆、腹泻、失眠。结论阿瑞匹坦联合昂丹司琼及地塞米松在肺癌含顺铂化疗中止吐疗效好,连续6程化疗中止吐疗效持久。Objective To analyze the efficacy of aprepitant in the prevention of vomiting during multiple cycles of cisplatin-based chemotherapy in lung cancer.Methods 95 cases of patients with lung cancers who received four or six cycles of cisplatin-based chemotherapy were selected retrospectively.All the patients received antiemetic regimen including aprepitant:aprepitant(125 mg po D1,80 mg po D2~D3),ondansetron(8 mg iv bid D1~D3)and dexamethasone(5 mg iv D1-D3).The complete response rate of vomitting,nausea-free rate and adverse effect were observed.Results 24 and 73 patients received 4 and 6 cycles of cisplatin-based chemotherapy respectively.Complete response rates ranged from 71.2%to 78.9%with no significant decline during continuous cycles of chemotherapy.61.1%to 68.4%of patients were nausea-free during chemotherapy.The reported side effects were mild fatigue,constipation,hiccup,diarrhea and insomnia.Conclusion The combination of aprepitant,ondansetron and dexamethasone enhanced the antiemetic protection,and its efficacy was also sustained for up to six cycles of cisplatin-based chemotherapy in lung cancer patients.

关 键 词：阿瑞匹坦 肺癌 顺铂 多疗程化疗 恶心呕吐 

分 类 号：R975.4[医药卫生—药品]