2016年茂名市460例结核病耐药性监测数据分析  

Analysis of Drug Resistance Monitoring Data in 460 Cases of Tuberculosis Patients in Maoming City

作　　者：陈和勇[1] CHEN Heyong(Department of Clinical Laboratory,The Chronic Disease Prevention and Treatment Center of Maoming,Maoming 525000,China)

机构地区：[1]茂名市慢性病防治中心检验科,广东茂名525000

出　　处：《沈阳医学院学报》2018年第4期329-331,共3页Journal of Shenyang Medical College

摘　　要：目的:分析茂名市2016年结核病耐药性监测项目中初治、复治肺结核患者的耐药情况。方法:选择2016年1月至12月茂名市登记的474例痰标本培养阳性肺结核患者,将痰培养阳性菌株送至我中心进行菌种鉴定,并进行9种抗结核药物的药敏试验,分析原发性耐药、获得性耐药、耐多药、多耐药情况。结果:460例结核分枝杆菌菌株药敏试验显示,菌株耐药顺位从高到低依次为乙胺丁醇(24.78%)、异烟肼(17.17%)、利福平(14.35%)、链霉素(11.74%)、对氨基水杨酸(10.00%)、卡那霉素(5.22%)、氧氟沙星(4.78%)、卷曲霉素(1.96%)、乙硫异烟胺(1.30%);初治患者对一线抗结核药物单耐药率为13.33%,复治患者为8.62%,差异有统计学意义(P<0.05);初治患者多耐药率为8.89%,耐多药率为2.22%,复治患者分别为14.15%和9.85%,2组多耐药率、耐多药率差异均有统计学意义(P<0.05)。结论:茂名市复治肺结核患者耐药结核病控制较好,但复治患者耐多药、多耐药状况仍较严重,应加强全市范围内结核病防控管理工作。Objective:To analyze the drug resistance of newly diagnosed and retreated tuberculosis patients in Maoming tuberculosis surveillance program in 2016.Methods:A total of 474 cases of tuberculosis patients with tuberculosis positive in sputum specimens were selected as research objects in Maoming city from Jan 2016 to Dec 2016.The positive strains of sputum culture were sent to our center to identify the strains,and the drug sensitivity tests of 9 anti-tuberculosis drugs were carried out to analyze the situation of primary,acquired resistance,multiple drug resistance and multi-drug resistance.Results:The drug sensitivity test of 460 Mycobacterium tuberculosis strains showed that the sequence of drug resistance from high to low was EMB(24.78%),INH(17.17%),RFP(14.35%),SM(11.74%),PAS(10.00%),KM(5.22%),OFX(4.78%),CM(1.96%),PTO(1.30%).The single drug resistance rate of first-line anti-tuberculosis drugs was 13.33%for newly diagnosed patients,and that in the retreated patients were 8.62%(P<0.05).The multiple drug resistance rate of the newly diagnosed patients was 8.89%,the multi-drug resistance rate was 2.22%,and those in the retreated patients were 14.15%and 9.85%respectively,the difference was statistically significant(P<0.05).Conclusions:The drug resistant tuberculosis of the patients with retreated pulmonary tuberculosis in Maoming is well controlled,but the multiple drug resistance and multi-drug resistance of the retreated patients are still serious,and the management of tuberculosis prevention and control in the whole city should be strengthened.

关 键 词：结核病 耐药性 监测 

分 类 号：R521[医药卫生—内科学]